40 courses with the subject BIOL GU, each shown exactly as we captured it from the college's catalog, with every element we hold. Where the wording looks broken, that is our reading of the catalog, not the college's text.
BIOL GU4001ADVANCED GENETIC ANALYSIS3.00
Prerequisites: for undergraduates: Introductory Genetics (W3031) and the instructor's permission. Prerequisites: for undergraduates: Introductory Genetics (W3031) and the instructors permission. This seminar course provides a detailed presentation of areas in classical and molecular genetics for advanced undergraduates and beginning graduate students. Topics include transmission genetics, gain and loss of function mutations, genetic redundancy, suppressors, enhancers, epistasis, expression patterns, using transposons, and genome analysis. The course is a mixture of lectures, student presentations, seminar discussions, and readings from the original literature
This course has three interrelated goals: (i) to develop an intuitive understanding of the thermodynamic forces that control the structure of biological macromolecules and the evolution of life, (ii) to learn how to apply that understanding to experimental analyses of macromolecular interactions, and (iii) to master the use of molecular graphics software for understanding and interpreting macromolecular structures and interactions. The lectures develop the essential thermodynamic theory from the ground up, starting from a review of the relevant physical forces (Newton's and Coulomb's Laws) and culminating with an intuitive explanation of how complex biological organisms can evolve spontaneously, in a universe in which all natural processes are driven by increasing randomness or entropy, as specified by the 2nd Law of Thermodynamics. Subsequent lectures elaborate how these thermodynamic principles govern the formation and interaction of macromolecular structures, which represent the physical foundation for the evolution of life, and how the same principles are applied to analyze related experimental data. The problem sets for the course focus on practical applications of these principles to the analysis of data from common experiments used by molecular biologists to characterize macromolecular interactions. Extensive use is made of molecular graphics software throughout the semester, including in the problem sets, based on instruction provided in both the lectures and recitation sections. The course is designed to develop a deep understanding of the physical mechanisms controlling macromolecular interactions while simultaneously empowering students to critically read related literature and rigorously design and analyze related experiments themselves
Prerequisites: one year of biology; a course in physics is highly recommended. Lecture and recitation. This is an advanced course intended for majors providing an in depth survey of the cellular and molecular aspects of nerve cell function. Topics include the cell biology and biochemistry of neurons, ionic and molecular basis of electrical signals, synaptic transmission and its modulation, function of sensory receptors. Although not required, it is intended to be followed by Neurobiology II (see below). The recitation meets once per week in smaller groups and emphasizes readings from the primary literature
BIOL GU4011Circuits in the Brain: Dendritic integration3.00
This course is an advanced seminar that will review current knowledge about the computation carried out by microcircuits present in the mammalian CNS. This year the seminar will focus on dendritic integration and in the function of dendritic spines. The class will run as a seminar discussion, where it is assumed that every student will have studied the reading material ahead of time and will be knowledgeable enough to explain it. Students should expect a minimum of 9 hours of work / week (classroom work at home combined)
Prerequisites: BIOL C2005-C2006 or equivalent. Come discover how the union of egg and sperm triggers the complex cellular interactions that specify the diverse variety of cells present in multicellular organisms. Cellular and molecular aspects of sex determination, gametogenesis, genomic imprinting, X-chromosome inactivation, telomerase as the biological clock, stem cells, cloning, the pill and cell interactions will be explored, with an emphasis on humans. Original research articles will be discussed to further examine current research in developmental biology. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisites: genetics or molecular biology. The course covers techniques currently used to explore and manipulate gene function and their applications in medicine and the environment. Part I covers key laboratory manipulations, including DNA cloning, gene characterization, association of genes with disease, and methods for studying gene regulation and activities of gene products. Part II also covers commercial applications, and includes animal cell culture, production of recombinant proteins, novel diagnostics, high throughput screening, and environmental biosensors
BIOL GU4036Transformative Concepts in Systems Biology3.00
Systems biology approaches are rapidly transforming the technological and conceptual foundations of research across diverse areas of biomedicine. In this course we will discuss the fundamental developments in systems biology with a focus on two important dimensions: (1) the unique conceptual frameworks that have emerged to study systems-level phenomena and (2) how these approaches are revealing fundamentally new principles that govern the organization and behavior of cellular systems. Although there will be much discussion of technologies and computational approaches, the course will emphasize the conceptual contributions of the field and the big questions that lie ahead. Lectures and discussions of primary literature will enable students to scrutinize research in the field and to internalize systems biology thinking in their own research. To make this a concrete endeavor, the students will develop mini-NIH-style grant proposals that aims to study a fundamental problem/question using systems biology approaches. The students will then convene an in-class NIH-style review panel that will assess the strengths and weaknesses of these proposals. In addition, the students will have the opportunity to defend their proposals in a live presentation to the class. The course is open to graduate students in Biological Sciences. Advanced undergraduates in biological sciences, and other graduate students with background in biology from other disciplines, including physics, chemistry, computer science, and engineering may also attend after consulting with the instructor
Enrollment limited to 30. Molecular and cellular basis of infectious diseases and inherited propensities. Mechanisms of disease examined in discussions based on current research papers. Lectures, discussions, and student presentations. Essay required in lieu of final examination.
Prerequisites: Two semesters of a rigorous, molecularly-oriented, introductory biology course, such as UN2005 (Inc., Biochemistry of DNA ＆ Proteins, basic Genetics, Metabolism ＆ Cell Physiology) and UN2006 (Cell biology, inc. intra-cellular transport, phagocytosis, protein regulation, as well as Inter-cellular communication, inc., cell-cell contact, receptors/ligands ＆ transporters). This course will cover the integration of innate and adaptive immune systems, as well as how immune response contributes to health and disease (e.g., Infectious disease, allergies, autoimmunity, immune deficiencies, the microbiome and cancer immunotherapy). Students will also become familiar with important immunological methods, which will provide an opportunity to explore some of the current literature. Sophomores will require permission from their advisor to enroll, and graduate student will require the instructor’s permission to enroll. SPS, Barnard, and TC students may register for this course with the instructor’s approval on a Registration Adjustment Form (Add/Drop form), which can be downloaded ( http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf) and then returned to the office of the registrar
Prerequisites: one year each of biology and physics, or the instructor's permission. Prerequisites: one year each of biology and physics, or the instructor's permission. This is a combined lecture/seminar course designed for graduate students and advanced undergraduates. The course will cover a series of cases where biological systems take advantage of physical phenomena in counter intuitive and surprising ways to accomplish their functions. In each of these cases, we will discuss different physical mechanisms at work. We will limit our discussions to simple, qualitative arguments. We will also discuss experimental methods enabling the study of these biological systems. Overall, the course will expose students to a wide range of physical concepts involved in biological processes
Prerequisites: BIOC UN3512 RNA has recently taken center stage with the discovery that RNA molecules sculpt the landscape and information contained within our genomes. Furthermore, some ancient RNA molecules combine the roles of both genotype and phenotype into a single molecule. These multi-tasking RNAs offering a possible solution to the paradox of which came first: DNA or proteins. This seminar explores the link between modern RNA, metabolism, and insights into a prebiotic RNA world that existed some 3.8 billion years ago. Topics include the origin of life, replication, and the origin of the genetic code; conventional, new, and bizarre forms of RNA processing; structure, function and evolution of key RNA molecules, including the ribosome, and RNA therapeutics including vaccines. The format will be weekly seminar discussions with presentations. Readings will be taken from the primary literature, emphasizing seminal and recent literature. Requirements will be student presentations, class participation, and a final paper
BIOL GU4082Theoretical Foundations and Applications of Biophysical Methods4
Rigorous introduction to the theory underlying biophysical methods, which are illustrated by practical applications to biomedical research. Emphasizes the approach used by physical chemists to understand and analyze the behavior of molecules, while also preparing students to apply these methods in their own research. Course modules cover: (i) statistical analysis of data; (ii) solution thermodynamics; (iii) hydrodynamic methods; (iv) light-scattering methods; and (v) spectroscopic methods, especially fluorescence. Recitations focus on curve-fitting analyses of experimental data.
BIOL GU4088Seminar in Neurobiochemistry and Neurological Diseases3.00
Students will read and discuss classical as well as contemporary research papers on the molecular and cellular mechanisms of membrane excitability, synaptic transmission and sensory transduction, and the pathogenic mechanisms and therapeutics of certain neurological diseases related to these processes. Focus will be on intellectual creativity, conceptual breakthroughs, and technical advances. A key goal of the course is to help students become a critical reader and thinker. Graduate students in all disciplines are welcome. Advanced undergraduate students can enroll with instructor’s permission. For PhD students in the Biological Sciences Program, this is a tier 3 course
The course examines current knowledge and potential medical applications of pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells), direct conversions between cell types and adult, tissue-specific stem cells (concentrating mainly on hematopoietic and gut stem cells as leading paradigms). A basic lecture format will be supplemented by presentations and discussions of research papers. Recent reviews and research papers together with extensive instructor notes will be used in place of a textbook.
This course deals with the proteome: the expressed protein complement of a cell, organelle, matrix, tissue, organ or organism. The study of the proteome (proteomics) is broadly applicable to life sciences research, and is increasingly important in academic, government and industrial research through extension of the impact of advances in genomics. These techniques are being applied to basic research, exploratory studies of cancer and other diseases, drug discovery and many other topics. Emphasis will be on mastery of practical techniques of sample preparation, liquid chromatography/ mass spectrometry (LC/MS) with electrospray ionization, and Matrix-Assisted Laser Desorption and Ionization (MALDI-TOF) mass spectrometry. Database searching and interpretation for identification of proteins will be intensively studied, and practiced supported by background tutorials and exercises covering other techniques used in proteomics. Open to students in M.A. in Biotechnology Program (points can be counted against laboratory requirement for that program), Ph.D. and advanced undergraduate students with background in genetics or molecular biology. Students should be comfortable with basic biotechnology laboratory techniques as well as being interested in doing computational work in a Windows environment
Prerequisites: (BIOL UN2005 or BIOL UN2401) or Prerequisites: (BIOL UN2005 or BIOL UN2401) or BIOL UN2005 or BIOL UN2401 or equivalent This is an advanced microscopy course aimed at graduates and advanced undergraduate students, who are interested in learning about the foundational principles of microscopy approaches and their applications in life sciences. The course will introduce the fundamentals of optics, light-matter interaction and in-depth view of most commonly used advanced microscopy methods, explore important practical imaging parameters, and also introduce digital images and their analysis
Prerequisites: four semesters of biology with a firm foundation in molecular and cellular biology. Prerequisites: four semesters of biology with a firm foundation in molecular and cellular biology. Introduces students to the current understanding of human diseases, novel therapeutic approaches and drug development process. Selected topics will be covered in order to give students a feeling of the field of biotechnology in health science. This course also aims to strengthen students’ skills in literature comprehension and critical thinking
Prerequisites: BIOL W4300 or the instructors permission. A weekly seminar and discussion course focusing on the most recent development in biotechnology. Professionals of the pharmaceutical, biotechnology, and related industries will be invited to present and lead discussions
The basic thesis of the course is that all viruses adopt a common strategy. The strategy is simple: 1. Viral genomes are contained in metastable particles. 2. Genomes encode gene products that promote an infectious cycle (mechanisms for genomes to enter cells, replicate, and exit in particles). 3. Infection patterns range from benign to lethal; infections can overcome or co-exist with host defenses. Despite the apparent simplicity, the tactics evolved by particular virus families to survive and prosper are remarkable. This rich set of solutions to common problems in host/parasite interactions provides significant insight and powerful research tools. Virology has enabled a more detailed understanding of the structure and function of molecules, cells and organisms and has provided fundamental understanding of disease and virus evolution. The course will emphasize the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles, the interactions of viruses with host organisms, and how these lead to disease are presented with examples drawn from a set of representative animal and human viruses, although selected bacterial viruses will be discussed. Spring 2026: BIOL GU4310 Course Number Section/Call Number Times/Location Instructor Points Enrollment BIOL 4310 001/13890 M W 4:10pm - 5:25pm 209 Havemeyer Hall Vincent Racaniello 3 101/110
This course provides a rigorous introduction to the theory underlying widely used biophysical methods, which will be illustrated by practical applications to contemporary biomedical research problems. The course has two equally important goals. The first goal is to explain the fundamental approaches used by physical chemists to understand the behavior of molecules and to develop related analytical tools. The second goal is to prepare students to apply these methods themselves to their own molecular biology research projects. The course will be divided into seven modules: (i) solution thermodynamics with an emphasis on application to analysis of protein structure, folding, and binding interactions; (ii) hydrodynamic methods; (iii) statistical analysis of experimental data; (iv) molecular dynamics calculations; (v) optical spectroscopy with an emphasis on fluorescence; (vi) nuclear magnetic resonance spectroscopy; and (vii) light-scattering and diffraction methods including an overview of cryogenic electron microscopy reconstruction methods. In each module, the underlying physical theories and models will be presented and used to derive the mathematical equations applied to the analysis of experimental data. Weekly recitations will emphasize the analysis of real experimental data and understanding the applications of biophysical experimentation in published research papers. The problem sets emphasize use of PyMOL for analysis of macromolecular structures and use of standard curve-fitting software for analysis of protein binding data; detailed tutorials on the related methods are provided in the recitation sections. The first three modules will be covered in Biophysical Chemistry I during the fall term, while the final three will be covered in Biophysical Chemistry II during the spring term, and treatment of molecular dynamics calculations will be divided between the two terms
We will aim for practical understanding of the fundamentals of Python programming, image visualization ＆ rendering tools and common image processing tasks, including image segmentation, measurements of features and registration
In this course, we will explore the basic biochemistry of living systems and how this knowledge can be harnessed to create new medicines. We will learn how living systems convert environmental resources into energy through metabolism, and how they use this energy and these materials to build the molecules required for the diverse functions of life. We will discuss the applications of this biochemical knowledge to mechanisms of disease and to drug discovery. We will look at examples of drug discovery related to neurodegeneration, cancer, and the SARS-CoV-2 COVID19 pandemic. This course satisfies the requirement of most medical schools for introductory biochemistry, and is suitable for advanced undergraduates, and beginning graduate students. This course is equivalent to and replaces the prior course named UN3501, and is equivalent to the course offered in the summer
BIOL GU4505Biochemistry I Recitation in VR: Leveraging Virtual Reality0.00
In this course, we will use virtual reality to explore the basic biochemistry of living systems and how this knowledge can be harnessed to create new medicines. We will learn how living systems convert environmental resources into energy through metabolism, and how they use this energy and these materials to build the molecules required for the diverse functions of life. We will discuss the applications of this biochemical knowledge to mechanisms of disease and to drug discovery. We will look at examples of drug discovery related to neurodegeneration, cancer, and the SARS-CoV-2 COVID19 pandemic. This course satisfies the requirement of most medical schools for introductory biochemistry, and is suitable for advanced undergraduates, and beginning graduate students. This course is equivalent to and replaces the prior course named UN3501, and is equivalent to the course offered in the Fall semester. This course is a co-requisite to GU4501. We will meet twice each week in Zoom (Tuesday and Thursday 2:30-5:15, GU4501) to discuss the course material. We will then meet Friday 9:30-10:30 each week in virtual reality, using the Spatial.io platform and an Oculus Quest headset. In VR, we will examine the 3D spatial concepts relevant to biochemistry, where you will be able to examine molecular structures in an immersive format
BIOL GU4506Biochemistry I in XR: Mixed Reality1.00
In this course, we will use mixed reality to explore the basic 3D aspects of biochemistry of living systems and how this knowledge can be harnessed to create new medicines. Students may register for this course alongside of GU4501 or independent of GU4501. Professor Stockwell will meet each week with a group of 4 students to discuss protein structures using Oculus Quest Pro Mixed Reality headsets in the XR app Nanome. Students will rotate through in person meetings but can join all weekly sessions using a virtual live stream. We will examine 3D spatial concepts relevant to biochemistry, where you will be able to examine molecular structures in an immersive format in real time with other students and with the instructor
Prerequisites: one year of Biology, Chemistry, and Physics. Courses taken at CU are recommended, but AP courses may be sufficient with the instructor's permission.
BIOL GU4511Biochemistry I recitation: Structure and Metabolism0.00
This is the recitation for GU4501. How does life work on a molecular level? Why do we succumb to disease, and how can we create new cures? This course will explore the biochemistry of life and how this knowledge can be harnessed to create new medicines. You will learn how cells convert environmental resources into energy through metabolism, how cellular molecules function, and how to use this biochemical knowledge for drug discovery related to neurodegeneration, cancer, and the current SARS-CoV-2 COVID19 pandemic. At the conclusion of the course, you will be able to diagram the major metabolic pathways and compare how these pathways are dysregulated in normal tissues in and in disease states. In addition, you will know what techniques are used to uncover biochemical knowledge and how to interpret relevant experiments. You will be capable of collaborating with other people in the analysis and interpretation of biochemical data, and be able to communicate, defend and refute interpretations of data. Having completed one year of college-level biology and one year of organic chemistry will be helpful to maximally benefit from this course. This course satisfies the requirement of most medical schools for introductory biochemistry, and is suitable for advanced undergraduates, and beginning graduate students; this replaces the previous UN3511 course
Prerequisites: one year of biology. This is a lecture course designed for advanced undergraduates and graduate students. The focus is on understanding at the molecular/biochemical level how genetic information is stored within the cell, how it is replicated and expressed, and how it is regulated. Topics covered include genome organization, DNA replication and repair, transcription, RNA processing, and translation. This course will also emphasize the critical analysis of the scientific literature and help students understand how to identify important biological problems and how to address them experimentally. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
The course covers a general introduction to the theory and experimental techniques of structural biology (protein expression and purification, protein crystallography, cryo-electron microscopy, nuclear magnetic resonance) and then how to use the structural information to understand biochemical and biological processes. The first part of the course will cover the general introduction to structural biology. The second part of the course will involve discussions and explorations of various structures, led by the instructor but with substantial participation from the students, to understand the molecular mechanisms of selected biochemical and biological processes. In the final part of the course, each student will select and lead discussions on a primary structural biology paper. The overall goal of the course is to increase the understanding of how protein structures are determined, what protein structures look like, and how to use the structures to understand biology
From the notion of a type-specimen for a species to a wild-type mouse strain, biology has long relied on the idea of an archetype. In reality, however, there is variation everywhere one looks—no wild-type, only mutants. This variation is what makes some families taller than others or more susceptible to autism. Making sense of these differences is what led from the study of “the” human genome to that of millions of genomes. Notably, this goal is central to precision medicine, undergirding accurate disease risk prediction and tailored individual treatments. This shift in perspective poses new and fundamental questions, challenging us to understand how genetic perturbations and environmental effects together give rise to human difference. The goal of this course is to provide a basis for the study of such questions, by focusing on the causes and consequences of human genetic variation. It aims to provide a fundamental toolbox with which to approach human genetic data and to facilitate access to exciting developments in the field, from weekly discoveries about our prehistory to major developments in our understanding of the genetic basis for disease risk. The basis for the course is a new, freely available textbook, An Owner’s Guide to the Human Genome, by Jonathan Pritchard
Prerequisites: A strong background in molecular and cellular biology. Generally students with four or more courses are accepted. Cell Signaling is a graduate course for Ph.D. students open to advanced undergraduate and masters students. The basic molecular mechanism of signal transduction pathways will be discussed related to cell growth and stress systems. There will be an emphasis on specific categories of signaling components. Students will read the literature and give presentations. Topics include the pathways by which cells respond to extracellular signals such as growth factors and the mechanisms by which extracellular signals are translated into alterations in the cell cycle, morphology, differentiation state, and motility of the responding cells. For stress pathways we will discuss how cells respond to survive the stress or induce their own death. In many cases these pathways will be related to human diseases
BIOL GU4777From Curiosity to Cure – Case Studies in Cool Biochemistry4.00
Course overview: The goal of this course is to engage upper-level undergraduates and beginning graduate students in an immersive intellectual experience at the intersection of rigorous scientific inquiry and the history of innovation in molecular biology. The central theme will be curiosity and critical thinking as the twin drivers of both technological innovation and scientific discovery. The course will be divided into a series of modules focused on analysis and presentation of original research papers related to one important breakthrough in molecular biology that occurred during the past century. A prominent theme of the course will be the persistently unpredictable trajectory linking technical research and methodological developments to breakthrough science. Approximately six-to-eight original research papers will be covered in each module, spanning topics from the development of the methods that made the breakthrough possible through practical application of the resulting knowledge. Three or four of the following breakthroughs will likely be covered in 2023: Discovery and clinical application of insulin by Banting ＆ Best. Development of the Trikafta triple drug treatment for cystic fibrosis. Development of CRISPR for human genetic engineering. Genetics and pharmacological treatment of human hyperlipidemia. Development of the Gleevec tyrosine kinase inhibitor to cure Ph leukemias. Development of “next-generation” nucleic acid sequencing methods
Tracing the discovery of the role of DNA tumor viruses in cancerous transformation. Oncogenes and tumor suppressors are analyzed with respect to their function in normal cell cycle, growth control, and human cancers. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
