52 courses with the subject BIOL UN, each shown exactly as we captured it from the college's catalog, with every element we hold. Where the wording looks broken, that is our reading of the catalog, not the college's text.
BIOL UN1002Theory and Practice of Science: Biology4
CC/GS: Partial Fulfillment of Science Requirement Lecture and recitation. By analysis and example from the primary literature of evolution and genetics, examines how scientific theories are invented and how they come to be accepted, verified, and in some cases rejected. Papers begin with Darwin and Mendel and end with Watson. Ordinarily does not fulfill biology major or concentration requirements. Normally may not be taken for credit by any student who has previously completed any biology course numbered 2000 or above. BIOL UN1015 should be taken first then BIOL UN1002 for nonscience majors.
General Chemistry I is a pre-requisite; General Chemistry II is a pre/co-requisite. In this course, we will introduce basic terminology, important concepts, and basic problem-solving skills in order to prepare biology and pre-health students for the challenging Biology courses they will take at Columbia. We will do a deep dive into a small number of topics and use these as access points to teaching skills that will aid students in future STEM courses. Classes will include time for problem solving. Recitations will involve problem solving and student presentations of solutions to problems
Prerequisites: one year of high school or college biology. Prerequisites: one year of high school or college biology. This course covers selected topics in genetics and developmental biology, with special emphasis on issues that are relevant to contemporary society. Lectures and readings will cover the basic principles of genetics, how genes are expressed and regulated, the role of genes in normal development, and how alterations in genes lead to abnormal development and disease. We will also examine how genes can be manipulated in the laboratory, and look at the contributions of these manipulations to basic science and medicine, as well as some practical applications of these technologies. Interspersed student-run workshops will allow students to research and discuss the ethical and societal impacts of specific topics (e.g. in vitro fertilization, uses and misuses of genetic information, genetically modified organisms, steroid use, and cloning). SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
BIOL UN1201Engineered Mouse Models and Identifying Phenotypes In Vivo1.50
This undergraduate lecture course will introduce how transgenic and mutant mouse models are generated and their utility in defining the functional roles of genes in vivo. Classically, the function of a gene is tested in vivo by either overexpressing or inactivating its expression, leading to a gain-of-function or loss-of-function phenotype from which is inferred a gene’s normal role in homeostasis. Here we will explore the classic strategies for the generation of transgenic and knockout mice, comparing and contrasting their individual strengths and weaknesses, while exploring the phenotypes that have resulted from these changes in gene expression. Using a subset of primary papers, students will be introduced to research analysis to become more versed in the layers of experimental design needed to identify a gene’s function in vivo. The theoretical timing and the strategy needed to design such experiments with these transgenic and mutant mouse models, and the power of stem cell experiments will be discussed. In addition, to develop critical and additional analytical skills, students will become versed in basic tissue histology and immunohistochemistry, using processed paraffin-embedded mouse tissues from wild-type and engineered mutant mouse lines. Students will learn how to recognize numerous, normal adult tissues with light microscopy and to identify proliferative zones vs. fully differentiated layers within each. In addition, they will analyze the development of mid-to-late gestational embryos in serial sections, to underscore the coordinated transformation of tissues required for normal embryonic development. Finally, serial sections from well-defined mutant mouse models will used to identify and characterize abnormal phenotypes resulting from the knock-out of genes encoding cell cycle regulators or tumor suppressors. Live animal handling or experimentation is not a component of this course
BIOL 1360 is a seminar for undergraduates in any class who are interested in exploring the complex relationships between science and society, some of which have become especially prominent and controversial during the past several months. I have enjoyed teaching this course for nearly a decade, at Columbia and elsewhere, based in part on my own experiences conducting and overseeing biomedical research at academic and governmental institutions. Many of our discussions will be built upon the foundational philosophy outlined in a famous short essay by Vannevar Bush and adopted by the US government shortly after World War Two. His essay helped to define the relationships---among government, academia, and industry---that influence how scientific work is conducted and supported, how universities operate, and how our nation’s economy, health, security, and prestige rise and fall. The course addresses a wide array of topics, such as: why do people choose a scientific career? why do governments and other funders support scientific work? how does science fail? why is there skepticism about science? how is it represented in the arts? how are results disseminated, evaluated, and legally protected? These questions and others are addressed from numerous perspectives, with examples taken from many fields of science, mostly biology and medicine, including the Covid-19 pandemic, biotechnology, and others. I will provide assignments for each class --- mainly short articles (from newspapers and scientific journals) and book chapters, but also a few films and short books --- at least a week in advance as topics for discussion. There will be no final exam or other written tests, but every student will undertake a term project on a topic developed through private consultations with me, and will present the findings orally in class and in a short essay. I welcome undergraduate students from all classes who are concentrating in any field: the natural or social sciences, humanities, or the arts. There are no prerequisites, other than an interest in how the scientific enterprise works and how it interacts with other components of our society
This seminar focuses on the biochemistry, biology, and sociology of DNA and its use and potential for misuse. Even before the discovery of the human genome, the DNA that is the lattice of each human being has been thought to be static and determinative. More recently, with advances in sequencing that DNA, the emerging picture is much more complex. Even so, deeply held beliefs about being solely “my DNA” have persisted affecting our entire species. Students in this seminar are expected to critically discuss and examine the ethical and societal impacts of several topics related to DNA (e.g., artificial reproductive techniques, eugenics, bodily autonomy, definitions and treatment of diseases, neuroscience, epigenetics and the microbiome), as well as the underlying biology and biochemistry of DNA. Human identity and its relationship to DNA is examined using an interdisciplinary framework of perspectives, including those originating from biology, genetics, medicine, public health, psychiatry, religion, and the law. Students are expected to draw from their own experiences as an individual in reflection through the readings to complete the written coursework and participate each week in class discussion. This seminar also allows for expression in other modalities (e.g., visual or aural), in a two-part final class project consisting of a media component in addition to a final written assignment
If you are interested in biology, come hear Columbia University professors discuss their biology-related research. Find out how the body works, the latest therapies for disease and maybe even find a lab to do research in. http://www.columbia.edu/cu/biology/courses/UN1908/index.htm
Prerequisites: one year of college chemistry, or a strong high school chemistry background. Prerequisites: one year of college chemistry is required. Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisites: EEEB W2001 or BIOL C2005, or the instructor's permission. Prerequisites: BIOL UN2005, or the instructors permission. Lecture and recitation. Recommended second term of biology for majors in biology and related majors, and for premedical students. Cellular biology and development; physiology of cells and organisms. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf . Students must register for a recitation section BIOL UN2016
Lecture and recitation. Recommended as the introductory biology course for biology and related majors, and for premedical students. Fundamental principles of biochemistry, molecular biology, and genetics. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Corequisites: BIOL UN2006 Prerequisites: Prerequisites: Course does not fulfill Biology major requirements or premedical requirements. Enrollment in laboratory limited to 16 students per section. Corequisites: BIOL UN2006 Prerequisites: Course does not fulfill Biology major requirements or premedical requirements. Enrollment in laboratory limited to 16 students per section. Exploration of the major discoveries and ideas that have revolutionized the way we view organisms and understand life. The basic concepts of cell biology, anatomy and physiology, genetics, evolution, and ecology will be traced from seminal discoveries to the modern era. The laboratory will develop these concepts and analyze biological diversity through a combined experimental and observational approach
This class focuses on how we gather reliable scientific evidence about human biology and public health. The aim is to help students better interpret and evaluate the scientific evidence that they will encounter throughout their lifetime, in primary papers but also as presented in news, advertisement, and politics. To these ends, students will be introduced to basic definitions and concepts in statistics and epidemiology, including point estimates and measures of uncertainty, p-values, error rates, association and causation, different study designs, and selection bias. Readings will draw from a textbook as well as the primary literature. The second half of the course will turn to dissecting the representation and misrepresentation of scientific evidence presented in different venues. It will draw primarily from the textbook “Calling Bullshit” and include discussions of timely examples from the news
Prerequisites: a course in college chemistry or the written permission of either the instructor or the premedical adviser. Prerequisites: one year of college chemistry or the written permission of either the instructor or the premedical adviser is required. Recommended as the introductory biology course for science majors who have completed a year of college chemistry and premedical students. The fundamental principles of biochemistry, molecular biology, and genetics. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisites: a course in college chemistry and BIOL C2005 or F2401, or the written permission of either the instructor or the premedical adviser. Prerequisites: a course in college chemistry and BIOL UN2005 or BIOL UN2401, or the written permission of either the instructor or the premedical adviser. Cellular biology and development; physiology of cells and organisms. Same lectures as BIOL UN2006, but recitation is optional. For a detailed description of the differences between the two courses, see the course web site or http://www.columbia.edu/cu/biology/ug/advice/faqs/gs.html. SPS, Barnard, and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisite or corequisite: BIOL UN2005 or BIOL UN2401. Contemporary Biology Lab is designed to provide students with hands-on exploration of fundamental and contemporary biological tools and concepts. Activities include in depth study of mammalian anatomy and physiology through dissection and histology, as well as a series of experiments in genetics and molecular biology, with emphasis on data analysis and experimental technique
Due to COVID-19 related restrictions on in-person laboratory work, this course acts as a replacement for BIOL UN2501. This course will act as a virtual introduction to the practice of contemporary biology, with an emphasis on common laboratory methods, online tools, statistical analysis, styles of scientific reasoning, and science communication. Students will be expected to watch a weekly lecture, either in-person or via recording. Lab activities are designed to be highly interactive and collaborative to reflect the realities of biological research. Small groups of students will work together on in-class activities, as well as on a long-term student-designed biological research project
Introductory Independent Biological Research is an opportunity for full-time undergraduates in the College, SEAS and GS interested in laboratory research to share in the work of an ongoing research program in our Department or in a comparable laboratory elsewhere in the university. Projects should address a specific biological problem. Clinical projects are not allowed. While most projects are laboratory-based, computational projects that address specific biological issues are allowed. This course differs from UN3500 in that it does not have prerequisites, does not require attendance at recitations, is graded P-D-F, and is graded solely by the sponsoring lab head. Course requirements listed on course website: https://biology.columbia.edu/content/biol-un2600-introductory-independent-biological-research
CC/GS: Partial Fulfillment of Science Requirement We can now determine the genetic makeup of any person in a matter of days and at a cost already within reach for many millions of people. For the past few years a movement has emerged to provide detailed genetic information directly to ordinary people, in some cases with the explicit aim of helping prospective parents to “eliminate preventable genetic disease” or, as one newspaper put it, to promote “genetically flawless babies.” But our technical capacity to both interrogate and manipulate the human genome has raced far ahead of serious consideration of the societal implications of doing so. This course will provide students with the background necessary to understand what has and will be done with the human genome and ultimately to help society formulate appropriate policies for wise stewardship of the human genome. To help illustrate the information available in the human genome and how it may influence individuals' lives, the instructors' will share and discuss their own and other public genomes in ways both molecular and personal.
If you are interested in biology, come hear Columbia University professors discuss their biology-related research. Find out how the body works, the latest therapies for disease and maybe even find a lab to do research in. Prerequisite: G Chem I ＆ II; Co-requisite: Intro bio I
Prerequisites: one year of biology; a course in physics is highly recommended. This is an advanced course intended for majors providing an in depth survey of the cellular and molecular aspects of nerve cell function. Topics include: the cell biology and biochemistry of neurons, ionic and molecular basis of electrical signals, synaptic transmission and its modulation, function of sensory receptors. Although not required, it is intended to be followed by Neurobiology II (see below)
Prerequisites: BIOL W3004, one year of biology, or the instructor's permission. Prerequisites: One year of biology, BIOL UN3004 or instructors permission in case the student hasn't take it. This course is the capstone course for the Neurobiology and Behavior undergraduate major at Columbia University. It is designed for advanced undergraduate and graduate students. Knowledge of Cellular Neuroscience (how an action potential is generated and how a synapse works) will be assumed. It is recommended that students take BIOL UN3004 Neurobiology I: Molecular and Cellular Neuroscience, or a similar course, or obtain instructors permission. Website for BIOLUN3005: https://blogs.cuit.columbia.edu/rmy5/files/2022/01/syllabus.UN3005.2022.v4-lab.pdf
Prerequisites: (BIOL UN2005 and BIOL UN2006) or (BIOL UN2401 and BIOL UN2402) BIOL C2005 & BIOL C2006 or BIOL F2401 & BIOL F2402, or the instructor's permission. In this primarily human physiology course, we will discuss how the major organ systems function, with an emphasis on cellular, molecular, and physical mechanisms. Organ systems covered include musculoskeletal, cardiovascular, respiratory, urinary, and digestive systems. Traditional lectures focus primarily on the normal functioning of organ systems, while pathophysiology is introduced through five case studies during the semester. After this course, students should be able to 1) describe the basic functioning of the major organ systems and how they contribute to homeostasis and health, 2) apply key concepts in physics and chemistry, such as flow, pressure/volume relationships, and mass action, to physiological systems, 3) use key concepts in molecular and cell biology to gain a mechanistic understanding of physiological processes, explain how organ systems work in an integrated way to achieve homeostasis and health, and 4) predict changes in organ function upon drug treatment, genetic mutation, or disease conditions
This course will present a quantitative description of the cellular physiology of excitable cells (mostly nerve and muscle). While the course will focus on examining basic mechanisms in cell physiology, there will be a thread of discussion of disease mechanisms throughout. The end of each lecture will include a discussion of the molecular mechanisms of selected diseases that relate to the topics covered in the lecture. The course will consist of two lectures per week. This course will be of interest to advanced (3000-4000 level) undergraduates that aim to pursue careers in medicine as well as those that will pursue careers in biomedical research. This course will also be of interest to graduate students desiring an introduction to the cellular physiology of nerve and muscle.
If an engineer were to build “the brain”, they would not be able to reproduce any of the brains that exist on Earth. Our brains were not designed to be perfect, but are a result of millions of years of evolution and adaptation. The goal of this course is to provide an overview of brain evolution, ranging from the evolution of the first neurons to the origin of the human brain. Specifically, the course will focus on recent insights emerging from studies of development, gene expression, and neural circuit architecture. The evolutionary perspective on commonly used terms, such as “neuron” and “brain”, and general principles of brain organization and function emerging from comparative studies will be discussed
Prerequisites: BIOL UN2005 and BIOL UN2006 BIOL C2005-C2006 or equivalent. Prerequisites: BIOL UN2005 and BIOL UN2006 or equivalent. Come discover how the union of egg and sperm triggers the complex cellular interactions that specify the diverse variety of cells present in multicellular organisms. Cellular and molecular aspects of sex determination, gametogenesis, genomic imprinting, X-chromosome inactivation, telomerase as the biological clock, stem cells, cloning, the pill and cell interactions will be explored, with an emphasis on humans. Original research articles will be discussed to further examine current research in developmental biology. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisites: (BIOL UN2005 and BIOL UN2006) Prerequisites: (BIOL UN2005 and BIOL UN2006) This course provides an introduction to Neurogenetics, which studies the role of genetics in the development and function of the nervous system (https://en.wikipedia.org/wiki/Neurogenetics). The course will be focused on teaching classic and contemporary concepts in genetics and neuroscience, rather than cataloguing mere facts. The course will emphasize the discovery processes, historical figures involved in these processes and methodologies of discovery. Primary research papers will be discussed in detail. A central organizational theme of the course is the presence of a common thread and narrative throughout the course. The common thread is an invertebrate model system, the roundworm Caenorhabditis elegans, which serves as a paradigm to show how simple genetic model systems have informed our view on the genetics of nervous system development and function. The ultimate goal of this course is to gain an understanding of the underlying principles of how the nervous system of one specific animal species forms, from beginning to end. The course is intended for neuroscience-inclined students (e.g. neuroscience majors) who want to learn about how genetic approaches have informed our understanding of brain development and function and, vice versa, for students with an interest in molecular biology and genetics, who want to learn about key problems in neuroscience and how genetic approaches can address them
Prerequisites: BIOL UN2005 and BIOL UN2006 or BIOL C2005-C2006 or the equivalent. Prerequisites: BIOL UN2005 and BIOL UN2006. General genetics course focused on basic principles of transmission genetics and the application of genetic approaches to the study of biological function. Principles will be illustrated using classical and contemporary examples from prokaryote and eukaryote organisms, and the experimental discoveries at their foundation will be featured. Applications will include genetic approaches to studying animal development and human diseases. SPS and TC students must obtain the written permission from the instructor, by filling out a Registration Adjustment Form (Add/Drop form). https://www.registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisites: one year of biology, normally BIOL C2005-C2006, or the equivalent. Prerequisites: one year of biology, normally BIOL UN2005-BIOL UN2006, or the equivalent. Cell Biology 3041/4041 is an upper-division course that covers in depth all organelles of cells, how they make up tissues, secrete substances important for the organism, generate and adapt to their working environment in the body, move throughout development, and signal to each other. Because these topics were introduced in the Intro Course (taught by Mowshowitz and Chasin), this course or its equivalent is a pre-requisite for W3041/4041. Students for whom this course is useful include biology, biochem or biomedical engineering majors, those preparing to apply for medical school or graduate school, and those doing or planning to start doing research in a biology or biomedical lab. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
BIOL UN3050Project Laboratory In Protein Biochemistry5
This course provides an intensive introduction to professional biomedical laboratory research. Students conduct a portion of an ongoing biochemical research project and write-up their results in a format suitable for publication in a peer-reviewed scientific research journal. Techniques in molecular biology and protein biochemistry are used to address a problem in mechanistic biochemistry or molecular pharmacology. Students are exposed to the full spectrum of techniques used in contemporary protein biochemistry, including molecular sequence analysis of genomic databases, molecular cloning and manipulation of recombinant DNA, protein expression in E. coli, protein purification, and biophysical characterization (typically including crystallization for x-ray structure determination). The couse emphasizes the use of critical thinking skills in scientific research while giving students the opportunity to apply the basic knowlegde learned in a wide variety of biology and chemistry lecture courses to a real research project. Examples of past projects can be found on the course website: https://www1.columbia.edu/sec/cu/biology/courses/w3050/class/index.html (cunix account required to login).
Prerequisites: one year of introductory biology and the instructor's permission. Multicellular animals contain a diverse array of cell types, yet start from a single cell. How do cells decide what kind of cell to be? In this lab course, we will use the tools of molecular biology and genetics to explore this fascinating question. We will use the nematode Caenorhabditis elegans, a powerful model organism used in hundreds of research labs. The course will be divided into three modules: C. elegans genetics, molecular cloning, and genetic screening. Laboratory techniques will include PCR, gel electrophoresis, restriction digest, ligation, transformation, RNAi, and C. elegans maintenance. Students will pursue original projects; emphasis will be placed on scientific thinking and scientific communication. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). Prerequisites: UN2005/UN2401 and UN2006/UN2402, or the equivalent at a different institution
Prerequisites: one year of Intro Bio. An introductory biology or chemistry lab is recommended. Prerequisites: one year of Intro Bio. An introductory biology or chemistry lab is recommended. Bacteria are not just unicellular germs. This lab course will broaden your awareness of the amazing world of microbiology and the diverse capabilities of microbes. The focus will be on bacterial multicellularity, pigment production, and intercellular signaling. Pigment-producing bacteria will be isolated from the wild (i.e. Morningside Campus or your skin), and characterized using standard genetic tools (PCR, DNA gel electrophoresis, transformation, screen) and microbiology techniques (isolation of bacteria and growth of bacterial colonies, media preparation, enrichment techniques for pigments). These techniques will also be applied in the study of bacterial multicellularity and signaling in the standard lab strain Pseudomonas aeruginosa. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisites: two semesters of a rigorous, molecularly-oriented introductory biology course (such as C2005 and C2006), or the instructor's permission. Prerequisites: two semesters of a rigorous, molecularly-oriented introductory biology course (such as UN2005 and UN2006), or the instructors permission. This course will cover the basic concepts underlying the mechanisms of innate and adaptive immunity, as well as key experimental methods currently used in the field. To keep it real, the course will include clinical correlates in such areas as infectious diseases, autoimmune diseases, cancer immunotherapy and transplantation. Taking this course wont turn you into an immunologist, but it may make you want to become one, as was the case for several students last year. After taking the course, you should be able to read the literature intelligently in this rapidly advancing field. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Prerequisites: three semesters of Biology or the instructors permission. The course examines current knowledge and potential medical applications of pluripotent stem cells (embryonic stem cells and induced pluripotent stem cells), direct conversions between cell types and adult, tissue-specific stem cells (concentrating mainly on hematopoietic and gut stem cells as leading paradigms). A basic lecture format will be supplemented by presentations and discussions of research papers. Recent reviews and research papers, together with extensive instructor notes, will be used in place of a textbook. SCE and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
Introduction to principles of general evolutionary theory, both nomological and historical; causes and processes of evolution; phylogenetic evolution; species concept and speciation; adaptation and macroevolution; concepts of phylogeny and classification.
Prerequisites: 1 year of Introductory Biology, 1 year General Chemistry, and 1st semester Organic Chemistry. Biochemistry is the study of the chemical processes within organisms that give rise to the immense complexity of life. This complexity emerges from a highly regulated and coordinated flow of chemical energy from one biomolecule to another. This course serves to familiarize students with the spectrum of biomolecules (carbohydrates, lipids, amino acids, nucleic acids, etc.) as well as the fundamental chemical processes (glycolysis, citric acid cycle, fatty acid metabolism, etc.) that allow life to happen. The course will end with a discussion of diseases that have biochemical etiologies. In particular, this course will employ active learning techniques and critical thinking problem-solving to engage students in answering the question: how is the complexity of life possible? NOTE: While only the 1st semester of Organic Chemistry is listed as a pre-requisite, it is highly recommended that you take all of Organic Chemistry beforehand
BIOL UN3320Regulation of Behaviors for Survival3.00
To maximize their survival animals must regulate their behavior in response to external environmental cues and their own internal state. A fundamental goal of neuroscience is to understand how neural circuits in the brain function to influence behavior. The aim of this course is to highlight the neural basis of innate behaviors that are critical for survival and discuss modern approaches to study the neuronal regulation of classically studied aspects of behavior. We will explore motor control (escape responses), sensory systems (vision, taste, and olfaction), and survival behaviors (feeding, drinking, mating, and aggression). Focus will be on recent and current research, the diversity of approaches for studying it, and how this knowledge can be applied to solve scientific questions. Students will read primary scientific literature and a significant portion of the course will be presentation and discussion-based
BIOL UN3404The Global Threat of Antimicrobial Resistance3.00
Prerequisites: (BIOL UN2005 and BIOL UN2006) or (BIOL UN2401 and BIOL UN2402) Antimicrobial resistant bacterial infections were estimated to account for 1.27 million deaths worldwide in 2019. The goal of the seminar is to provide an in-depth analysis of this ongoing threat. Discussions will include the molecular mechanisms, epidemiology of transmission and the consequences of antimicrobial resistant infections. It will also cover current efforts to reduce the spread and emergence of these difficult to treat pathogens, both in the community and the healthcare setting
Prerequisites: Concurrent with registering for this course, a student must register with the department and provide a written invitation from a mentor; details of this procedure are available at http://www.columbia.edu/cu/biology/courses/w3500/index.htm. Corequisites: BIOL UN3510 Prerequisites: Intro Bio I ＆ II. Students who have not taken Intro Bio are encouraged to register for BIOL UN2600. Concurrent with registering for this course, a student must register with the department and provide a written invitation from a mentor; details of this procedure are available at https://biology.columbia.edu/content/biol-un3500-independent-biological-research. Students must register for recitations UN3510 or consult the instructor. Corequisites: BIOL UN3510. Independent Biological Research is an opportunity for full-time undergraduates in the College, SEAS and GS interested in laboratory research to share in the work of an ongoing research program in our Department or in a comparable laboratory elsewhere in the region. Projects should address a specific biological problem. Clinical projects are not allowed. While most projects are laboratory-based, computational projects that address specific biological issues are allowed
Prerequisites: introductory genetics or the instructor's permission. Prerequisites: Introductory Biology I and II, or the instructors permission. This course introduces basic concepts in evolutionary biology, from speciation to natural selection. While the lectures incorporate a historical perspective, the main goal of the class is to familiarize students with topics and tools of evolutionary genetics as practiced today, in the era of genomics. Thus, the focus will be on evidence from molecular evolution and genetics and exercises will assume a basic background in genetics. Examples will be drawn from across the tree of life, but with a primary focus on humans
Prerequisites: concurrent with registering for this course, a student must register with the department, provide a written invitation from a mentor, and submit a research proposal. Prerequisites: concurrent with registering for this course, a student must register with the department, provide a written invitation from a mentor, and submit a research proposal. BIOL 3700 will provide an opportunity for students interested in independent research work in a hospital or hospice setting. In these settings, where patients and their needs are paramount, and where IRB rules and basic medical ethics make “wet-lab biology research” inappropriate, undergraduates may well find a way nevertheless, to assist and participate in ongoing clinical research. Such students, once they have identified a mentor willing to provide support, participation, and advising, may apply to the faculty member in charge of the course for 2-4 points/semester in BIOL W3700. This course will closely follow procedures already in place for BIOL 3500, but will ask potential mentors to provide evidence that students will gain hands-on experience in a clinical setting, while participating in a hospital- or hospice-based research agenda. A paper summarizing results of the work is required by the last day of finals for a letter grade; no late papers will be accepted
Prerequisites: three terms of biology (genetics and cell biology recommended). Prerequisites: three terms of biology (genetics and cell biology recommended). Cancer is one of the most dreaded common diseases. Yet it is also one of the great intellectual challenges in biology today. How does a cell become cancerous? What are the agents that cause this to occur? How do current findings about genes, cells, and organisms ranging from yeast cells to humans inform us about cancer? How do findings about cancer teach us new biological concepts? Over the past few years there have been great inroads into answering these questions which have led to new ways to diagnose and treat cancer. This course will discuss cancer from the point of view of basic biological research. We will cover topics in genetics, molecular and cell biology that are relevant to understanding the differences between normal and cancer cells. These will include tumor viruses, oncogenes, tumor suppressor genes, cell cycle regulation, programmed cell death and cell senescence. We will also study some current physiological concepts related to cancer including angiogenesis, tumor immunology, cancer stem cells, metastasis and new approaches to treatment that are built on recent discoveries in cancer biology. SPS and TC students may register for this course, but they must first obtain the written permission of the instructor, by filling out a paper Registration Adjustment Form (Add/Drop form). The form can be downloaded at the URL below, but must be signed by the instructor and returned to the office of the registrar. http://registrar.columbia.edu/sites/default/files/content/reg-adjustment.pdf
