1.300), 1.272 (95% CI: 1.058-1.528), 1.224 (1.105-1.355), and 1.267 (1.072-1.497), respectively]. Patients with variants in 2-4 of the genes had a significantly lower OS than patients with variants in 0-1 genes (HR: 1.405, 95% CI: 1.216-1.624). Through expression quantitative trait loci analysis of whole blood and lung tissue data, the minor allele of rs9643715 PEX2 was shown to be significantly associated with increased mRNA expression levels, while variants in rs6908167 PEX7 and rs4710806 FAM120B were significantly associated with decreased mRNA expression levels. Decreased expression of PEX7 and FAM120B in lung tumor tissue was also shown to be associated with decreased OS. Our data suggest that variants in these peroxisome-related genes may influence gene expression and are potential predictors of NSCLC OS, although further functional experiments should be done to investigate the biological mechanisms underlying associations between their variants NSCLC survival.
- Subject
- FAM
- Type
- course
- Edition
- 2026
- Source
- undergraduateresearch.duke.edu