as an antagonist in the striatum and an agonist in the cortex of mice. This allows 94A to treat both the positive and negative symptoms of schizophrenia. In our study, we seek to assess how 94A affects single unit recordings and local field potentials (LFPs) in the striatum and prefrontal cortex during antipsychotic action. Phencyclidine (PCP) is used to model schizophrenia in mice. One of the properties of 94A is decreasing PCP induced hyperlocomotion. Mice will be given 94A or vehicle and then given PCP before being placed in an open field arena for 160 minutes. LFP data will be analyzed to provide a better understanding of the neurophysiological impact of 94A administration as well as provide further evidence for its utility as an antipsychotic medication. Additional Authors: Fink AJ, Thomas GE, Chandrasekhar R, Caron MG, Dzirasa K VISIBLE THINKING - PRESENTATION OF UNDERGRADUATE RESEARCH
- Subject
- UNC
- Type
- course
- Edition
- 2026
- Source
- undergraduateresearch.duke.edu