CHEM

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The imperative to transform matter, find its roots in alchemy and the search for the Philosopher's Stone, which was thought to contain the secret of turning base metals into gold and also the secret of immortality. We will examine the evolution of the way in which people have thought about matter and its transformations; from the manufacturing of explosives to dyestuffs to pharmaceuticals and perfumes. We will do some simple experiments that demonstrate some of these principles. We will follow the development of the chemical sciences from the works of early alchemists to Renaissance (Newton and Boyle) scientists and modern thinkers (Priestly, Lavoisier, Dalton, Mendeleev and others). This class, which is designed for non-science as well as potential science majors, will involve discussions on readings, as well as field trips to some Philadelphia locations that are notable in the history of chemistry.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course will explore how biological properties are determined by the microscopic chemical properties of proteins and biomacromolecules. We will discuss how research results, especially those of structural biology, are presented to its various audiences.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Subject

CHEM

Type

course

Edition

2026

Source

www.college.upenn.edu

Subject

CHEM

Type

alias

Source

www.college.upenn.edu

or CHEM 1012 General Chemistry I or CHEM 1151 Honors Chemistry I

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

or CHEM 1151 Chemistry I or

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

less than one year of high school general Take the departmental chemistry, consider taking CHEM 001 placement exams for instead of CHEM 101. CHEM 101 and 102. (See Note #1 below.) If you pass both exams, you may If you do not pass either exam, If you receive credit for only one take more advanced chemistry you keep any CHEM 091 credit course, you should take the other classes. Students who pass either and take CHEM 101 and 102 course before moving on to more exam may apply for waivers for before moving on to more advanced chemistry classes. the labs (CHEM 053 or CHEM advanced chemistry classes. (See Note #3 below.) 054). (See Note #2 below.) (See Note #3 below.) Note #1 Note #2  Note #3 Students with less than one year Students who have passed one or more Students with two years of chem- of high school general chemistry chemistry placement exams can apply istry, including AP or IB, one year may choose to take CHEM 001, for lab waivers. Applications for lab of physics and one year of calculus which is similar to CHEM 101 waivers will not be evaluated unless a can also consider taking CHEM but includes a greater emphasis on student has passed one of the depart- 115 and 116, Honors General introductory concepts and prob- mental placement exams. Chemistry. lem solving. Class of 2018 Policies & Procedures 23

Subject

CHEM

Type

course

Edition

2026

Source

www.college.upenn.edu

or CHEM 1022 General Chemistry II or CHEM 1161 Honors Chemistry II General Chemistry Laboratories:

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

or CHEM 1161 Chemistry

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

& CHEM 1102 and General Chemistry Laboratory II Organic Chemistry with Laboratories:

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Continuation of CHEM 1101: General Chemistry Laboratory I

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Subject

CHEM

Type

alias

Source

www.college.upenn.edu

This course will focus on introducing students to the following topics: the nature of the chemical bond (forces, potentials, and quantum mechanics), covalent and non-covalent interactions, properties of gasses, liquids, and solids. Students will engage with chemistry research by analyzing recent publications on relevant topics from the chemical literature.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

An advanced course for students who have had very strong background in Chemistry in High School (AP, IB, or equivalent). Advanced material from the general chemistry curriculum will be covered in the context topics selected from current research areas. A continuation of CHEM 1151: Honors Chemistry I, CHEM 1161: Honors Chemistry II will focus on topics in biochemistry and biophysical chemistry relating to thermodynamics, equilibrium, kinetics, and electrochemistry. Prerequisite: Advanced High School Chemistry (AP or equivalent).

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The course aims to teach chemical content and principles in the context of significant environmental issues. Topics to be covered include: composition of the atmosphere; protecting the ozone layer; chemistry of global warming; traditional hydrocarbon fuels and energy utilization; water supply, its contaminants, and waste water treatment; acid rain; nuclear energy; and new energy sources. Students will develop critical thinking ability, competence to better assess risks and benefits, and skills that will lead them to be able to make informed decisions about technology-based matters.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

& CHEM 2220 and Physical Chemistry II or CHEM 2410 Principles of Organic Chemistry I & CHEM 2420 and Principles of Organic Chemistry II Total Course Units 36 You may count no more than one course toward both a Major and a Sector requirement. For Exceptions, check the Policy Statement (http:// www.college.upenn.edu/sectors-policy/).

Subject

CHEM

Credits (min)

2

Credits (max)

2

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

.00 Biological Chemistry Requirements .00

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Biological Chemistry:

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

or CHEM 2411 Principles of Organic Chemistry I with Laboratory Advanced Chemistry Elective: CHEM 2420, CHEM 2421, 1 CHEM 2210, MSE 2210

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Fundamental course in organic chemistry based upon the modern concepts of structure and mechanism of reactions. Laboratory included. Mutually Exclusive: CHEM 2410 (CHEM 1021 OR CHEM 1022 OR CHEM 1161) 1.5 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Prerequisite

(CHEM 1011 OR CHEM 1012 OR CHEM 1151) AND

Corequisite

CHEM 2412

Lab for CHEM 2411: Principles of Organic Chemistry I with Laboratory 0 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Corequisite

CHEM 2411

Continuation of CHEM 2410: Principles of Organic Chemistry I.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Continuation of CHEM 2411: Principles of Organic Chemistry I with

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Lab for CHEM 2421: Principles of Organic Chemistry II with Laboratory 0 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Prerequisite

CHEM 2411

Corequisite

CHEM 2421

A basic laboratory course in which both the theoretical and practical aspects of a variety of organic reactions and multistep syntheses are emphasized. Modern chromatographic, instrumental, and spectroscopic techniques are applied to experimental organic chemistry. CHEM 2410 is a required co-requisite for CHEM 2451 for Penn undergraduate students. LPS students may take CHEM 2410 as a pre-requisite or a co-requisite to CHEM 2451.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

A basic laboratory course in which both the theoretical and practical aspects of a variety of organic reactions and multistep syntheses are emphasized. Modern chromatographic, instrumental, and spectroscopic techniques are applied to experimental organic chemistry. CHEM 2420 is a required co-requisite for CHEM 2452 for Penn undergraduate students. LPS students may take CHEM 2420 (or equivalent) as a pre-requisite or a co-requisite to CHEM 2452.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Advanced laboratory work on the synthesis, structure, and properties of organic and inorganic compounds. Infrared, ultraviolet, and nuclear magnetic resonance spectroscopy. Lectures cover the theoretical basis and applications of modern spectroscopic methods.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Inorganic Chemistry:

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

One Advanced Laboratory:

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Independent project under the direction of a faculty member conducting chemistry research.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The degree and major requirements displayed are i for students entering in the Fall of 2026 and lat consult with their academic program regarding fina requirements for graduation. Sample Plan of Study

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Principles of statistical mechanics with applications to systems of chemical interest.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

A continuation of CHEM 5210. The course will emphasize the statistical mechanical description of systems in condensed phases.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The principles of quantum theory and applications to atomic systems.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Approximate methods in quantum theory and applications to molecular systems. Topics may include: electronic structure, configuration interaction, DFT, TD-DFT and response theory, electronic dynamics, semiclassical dynamics, vibrational density of states.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

or PHYS 6611Statistical Mechanics or PHYS 5500Mathematical Methods of Physics

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Theoretical and experimental aspects of important rate processes in chemistry.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course a high level overview of methods for the study of organic, organometallic, and inorganic reaction mechanism. CHEM 4410 (Mechanisms) or CHEM 5640 (Organometallics) is required. The course will survey thermodynamic and kinetic measurements used in understanding chemical reactions. Topics include kinetic measurements and interpretation, Arrhenius theory, Eyring theory, kinetic isotope effects, Hammett analyses, and electronic structure calculations. Articles discussing these techniques in delineating the reaction mechanisms for problems of current interest will be analyzed. The focus will be on experiments that can be accomplished with readily available analytical tools (NMR, IR, UV, GC, HPLC) and how an understanding of mechanism can be used to optimize reaction yields and selectivities.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

CHEM 5411 is a high level overview of classical physical organic chemistry. Undergraduate organic chemistry is a prerequisite. The course is divided into three parts. The first part will be an overview of organic bonding (basic molecular orbital theory, anomeric effect), structure (bond lengths, bond angles, conformational analysis), and properties (electronegativity, nucleophilicity, electrophilicity, acidity, basicity). The second part will be a brief overview of current computational methods including molecular mechanics, Hartree Fock, and density functional calculations. The focus will be on practical applications rather than the theory behind the calculations; students will be able to assess which calculations are most appropriate for a given task. The last part of the course will survey thermodynamic and kinetic measurements used in understanding organic chemical reactions. Topics include Hammett analyses, kinetic measurements and interpretation, the Hammond postulate, Arrhenius theory, Eyring theory, and kinetic isotope effects. Articles discussing these techniques in delineating the organic reaction mechanisms for problems of current interest will be analyzed. The focus will be on experiments that can be accomplished with readily available analytical tools (NMR, IR, UV, GC, HPLC) and how simple physical organic analyses can be used to optimize reaction yields and selectivities. 1 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Physical Organic I is an introduction to advanced physical organic chemistry. Mechanism drawing with arrows to denote the movement of an electron density will be a unifying theme. The course will overview organic bonding (basic molecular orbital theory, anomeric effect), structure (bond lengths, bond angles, delocalization and resonance, conformational analysis), and reactivity (electronegativity, nucleophilicity electrophilicity, acidity, basicity, stereoelectronics). 0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course a high level overview of methods for the study of organic, organometallic, and inorganic reaction mechanism. The preceding course Chem 5412 or its equivalent must be taken before this course. The course will briefly review basic mechanistic conventions (arrows, radical intermediates, etc.) and then more onto a survey thermodynamic and kinetic measurements used in understanding chemical reactions. Topics include kinetic measurements and interpretation, Arrhenius theory, Eyring theory, kinetic isotope effects, Hammett analyses, and electronic structure calculations. Articles discussing these techniques in delineating the reaction mechanisms for problems of current interest will be analyzed. The focus will be on experiments that can be accomplished with readily available analytical tools (NMR, IR, UV, GC, HPLC) and how an undertanding of mechanism can be used to optimize reaction yields and selectivities. 0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Introduction to advanced organic synthesis. Study of important synthetic reactions including: oxidations, reductions, and methods for the formation of carbon-carbon bonds, with an emphasis in chemoselectivity, stereoselectivity and asymmetric synthesis. Survey of modern methods for the synthesis of small, medium and large ring systems. Analysis of modern synthetic strategies, with illustrative examples from total synthesis of natural and unnatural products.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course focuses on organic reactions, reaction mechanisms, and the strategic applications of these reactions in organic synthesis. Topics include symmetry, stereochemistry, stereoselectivity, olefinations, olefin metathesis, transition-metal catalyzed cross couplings, cycloadditions, electrocyclizations, sigmatropic rearrangements, and other pericycylic reactions. The material will be illustrated by applications in multistep chemical synthesis. Based on this course, students should be able to read the modern literature, develop independent research proposals in organic chemistry, and succeed in graduate school. Recommended orbitals, hybridization, arrow pushing, stability, and reactivity. 0.5 Course Units

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Prerequisite

A basic understanding of Lewis structures, molecular

This half-semester course continues to emphasize organic reactions, reaction mechanisms, and their strategic applications in complex molecule synthesis. Topics covered include oxidations, reductions, carbon-carbon bond formations, and strategic applications of protecting groups. .5 Course Units University of Pennsylvania Catalog 1267

Subject

CHEM

Credits (min)

2

Credits (max)

2

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Prerequisite

CHEM 5412 AND CHEM 5431

Study of important types of reactions and functional groups, with emphasis on synthetic usefulness, mechanisms, and stereoelectronic principles.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Natural products, such as tetrodotoxin, kainic acid and morphine, have played a crucial role in the development of neuroscience. Using selected chemical syntheses as a framework, I will provide an introduction to neuroscience for chemists blended with an intense course in synthetic design ("Syntheseplanung"). The structure, function and synthesis of the following molecules will be analyzed: tetrodotoxin, saxitoxin, kainic acid, nicotine, epibatidine, coniine, tubocurarine, histrionicotoxin, ibotenic acid, strychnine, picrotine, chrysanthemic acid, ivermectin, muscarine, morphine, salvinorin A, THC, lysergic acid, forskolin, staurosporin, eglumegad, physostigmine, huperzin A, galanthamine, cocaine, reserpine, thapsigargin, ouabagenin, ryanodine, capsaicin, resiniferatoxin, retinal, carotene, menthol, santalol, camphor, and the prostaglandins. The structure and function of important ion channels, GPCRs, transporters and enzymes and their ligands will be discussed using PyMol files. The goal of this course is to get as many synthetic chemists excited about neuroscience as possible (and a few neuroscientists stoked about synthesis). The importance of structural and pharmacological databases (PDB and IUPHAR, respectively) and the usefulness of the Reaxys database (and SciFinder) for synthetic planning will be demonstrated. Requirements: A familiarity with synthetic organic chemistry and (named) chemical reactions, a mastery of the Nernst equation, and a willingness to learn more about one of the greatest, if not the greatest scientific challenges of our times: to figure out how the human brain work0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Structure, dynamics, and function of biological macromolecules. Properties of macromolecular assemblies, membranes and their compartments. (Formerly, CHEM 450-I).

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

BMB 5580 Optional Additions Include (1CU)

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The course surveys the chemical machinery of the cell, post-translational modifications of proteins and catalytic machinery of enzymes. Through this survey, students will become familiar with the cellular proteome and its facinating functions and dysfunctions that drive normal physiology and disease states of the cell. Current technologies for in vivo function assignment and unbiased drug-target discovery will be reviewed. Example topics include gene editing, protein profiling, targeted degradation, high-throughput drug screening and quantitative analysis of proteomes/metabolomes from native biological systems. The course couples in-class lecture and discussion with research demonstrations of select methods used for discovery.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course explores genome editing from the perspective of molecular mechanisms, biochemical principles, and evolutionary origins. It begins with natural nucleic acid-targeting systems involved in host defense and genome mobility, including restriction enzymes and CRISPR-based immunity, and develops CRISPR as a central example of how biological systems can be repurposed into programmable technologies. The course then extends to other evolution-derived platforms, including transposons, group II introns, and emerging RNA-guided systems, and examines modular enzymatic systems such as recombinases, integrases, and reverse transcriptases for genome manipulation. The final portion focuses on applications in functional genomics and therapeutic development, with emphasis on design strategies, delivery considerations, and current limitations. 1 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Reaction mechanisms in biological (enzymes, abzymes, ribozymes) and biomimetic systems with emphasis on principles of catalysis, role of coenzymes, kinetics, and allosteric control.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course will outline the physical chemical basis for enzyme catalysis. The kinetics and thermodynamics of substrate and inhibitor interactions will be discussed prior to an examination of paradigm systems. Topics will include enzymes involved in the regulation of various cellular functions, including proteases, enzymes of natural products biosynthesis, and enzymes of epigenetics. 0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

CHEM 5580 covers basic fluorescence spectroscopy and microscopy, as well as advanced topics such as single molecule spectroscopy and non- linear and super-resolution microscopies. There are weekly homework assignments that include problems based on the lectures as well as journal club style reports on by pairs of students on papers relevant to the course material.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

A detailed treatment of the theory and application of modern physical methods for the elucidation of structure and mechanism in inorganic and organometallic chemistry. An introduction to symmetry and group theory is followed by the application of these concepts to vibrational and electronic spectroscopy of inorganic complexes. Magnetic resonance is discussed in detail, including topics such as EPR, fourier transform methods, dynamic systems, and 2-dimensional NMR.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course provides an introduction to key concepts in inorganic chemistry, including an overview of the origins of periodic trends, an introduction to various bonding theories (crystal field theory, valence bond theory, and molecular orbital theory), and the kinetics of elementary reactions of coordination complexes. Density functional theory calculations will be performed by students (no experience necessary) to support key concepts developed in the course. 0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

or CHEM 5620

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course is focused on molecular species that contain metal-carbon bonds, and the role of these compounds in catalytic processes and organic synthesis. Aspects of the synthesis, structure and reactivity of important classes of organometallic compounds such as metallo alkyl, aryl, alkene, alkylidene and alkylidyne complexes are surveyed for the d and f block metals. Emphasis is placed on general patterns of reactivity and recurring themes for reaction mechanisms.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course encompasses a comprehensive survey of the chemistry and properties of the p-block elements of the periodic table. Topics include syntheses, structures and reactivities of important compounds. In addition, alternative bonding theories which have been used to explain the unique properties of thesecompounds are critically examined.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The course covers selected topics in bioinorganic chemistry; special emphasis is placed on dioxygen chemistry and electron transfer processes. Course topics include: (i) oxygen uptake and utilization; (ii) diatomic oxygen trans port; (iii) diatomic and monoatomic oxygen incorporation into substrates; (iv) metalloenzyme-catalyzed C-C bond formation; (v) the metallobiochemistry of DNA; (vi) metal-sulfide proteins; (vii) manganese-containing metalloproteins; (viii) Photosystem II: light- driven electron transfer and the biological water-splitting reaction; (ix) biological electron transfer; (x) electron transfer theory; (xi) mechanisms of energy storage and release; and (xii) long-distance electron transfer reactions.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

or CHEM 6011 Chemical Information for Biological Chemists or CHEM 6012 Chemical Information for Inorganic and Materials

Subject

CHEM

Credits (min)

1

Credits (max)

1

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course examines the structure and organization of the chemical literature in the field of biological chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Search skills are taught using a combination of lecture and laboratory activities, and students learn advanced text-based search techniques, protein and nucleotide sequence and structure similarity search strategies, basic substructure and reaction search strategies, and methods of retrieving property information and profiling substances by their properties. Students will also undertake a detailed examination protein and small molecule crystal structure databases. In addition to search skills, the students are exposed to strategies for choosing a publication venue; the use and limitations of citation information when evaluating authors, institutions, and journals; and the basic principles behind peer review. The semester closes with a brief introduction to personal data management and an in- depth discussion of the ethics surrounding scientific communication. The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in biochemistry or molecular biology research.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course examines the structure and organization of the chemical literature in the field of inorganic and materials chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Search skills are taught using a combination of lecture and laboratory activities, and students learn advanced text-based search techniques; advanced substructure and composition searches, with an emphasis on organometallic and inorganic substances and crystal structure data; reaction search techniques, focusing on catalyzed reactions; and methods of retrieving property information and profiling substances and materials by their properties. In addition to search skills, the students are exposed to strategies for choosing a publication venue; the use and limitations of citation information when evaluating authors, institutions, and journals; and the basic principles behind peer review. The semester closes with a brief introduction to personal data management and an in- depth discussion of the ethics surrounding scientific communication. The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in organometallic, inorganic, or materials chemistry.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

University of Pennsylvania Catalog 659

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course examines the structure and organization of the chemical literature in the fields of physical and theoretical chemistry chemistry and introduces techniques used to search this literature, focusing on the logic and thought processes necessary for effective information retrieval. The course takes an "under the hood" look at the organization and functionality of a variety of different databases and search systems, and, while learning information retrieval skills, students gradually become familiar with the structure of the chemical literature, the purposes of each genre, and the steps of the scientific publication process. Because of the diversity of research foci in physical and theoretical chemistry, the course is survey in nature, devoting time to a wide variety of tools and search strategies and demonstrating Penn’s collections in chemistry, mathematics, physics, materials science, and engineering. In addition to teaching search skills, we briefly examine methods of choosing a publication venue and the use and limitations of citation information when evaluating authors, institutions, and journals. The semester closes with a brief introduction to personal data management and a discussion of the ethics surrounding scientific communication. The course is taught at a level appropriate for graduate students and advanced undergraduates and requires permission of the instructor to register. Undergraduate students should have taken two semesters of organic chemistry prior to enrolling. Students should have an interest in physical or theoretical chemistry research.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Students will learn the key components in proposal writing and develop the skills needed to prepare a compelling and original graduate research proposal. The course involves significant writing, in-class discussions and presentations.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The ability to communicate original, written research proposals is essential to the modern chemist. This course, for graduate students in the organic and inorganic divisions, will promote development of proposal writing skills. Students will develop original ideas, practice written work, graphic design and peer review. Outcomes of the course will include writing (and submission, when eligible) of an NSF GRFP application and a 'proposed work' section of a candidacy exam report.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course examines the basic mathematics needed for physical chemistry, including (but not limited to) a brief review of linear algebra, Fourier transforms, delta functions, optimization, and the residue theorem. Depending on the year, selected other topics will also be included.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course discussed the structure of polymers from a statistical physics point of view as well as dynamical response of polymeric systems such as mechanical response of polymer melts, polymer glass transition, properties of polymers in solutions, and properties of block co- polymers and ionomers.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

will vary based on semester 0.5-1 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The course will provide a continuation of material covered in CHEM 5440 and CHEM 5410, as well as spectroscopy of organic compounds focused mainly on NMR. Topics will include advanced organic mechanisms, electronic structure calculations of organic molecules related to their structure, reactivity, and spectroscopic properties, and Organic Spectroscopic methods for the determination of structure using NMR.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

A Mass Spectrometry introductory course describing MS history, key ionization methods, mass analyzers, and MS methods for structure elucidation. The successful participant will be able to: Extract key information from stable isotope distribution patterns. Interpret key mass spectral fragment/product ions from a spectrum when acquired. Understand the differences between the major ionization sources. Understand the differences between the major mass analyzers. Determine reasonable ionization methods and analyzers for a sample or project. 0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The course will focus on Essential Practical NMR for Chemistry. Topics will include structure elucidation with 1D and 2D NMR spectra, how to obtain high quality NMR spectra on spectrometers, data processing with NMR software such as MNova and TOPSPIN, multi-nuclei NMR including 31P, 19F, 11B, 15N and 2H etc., dynamic and kinetic NMR, and some techniques to provide high resolution 2D NMR spectra.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development. Topics include the drug discovery process, drug targets (GRCR?s, enzymes, channels etc.), physical chemistry of molecular interactions between drug and target, drug design, methods for hit and lead identification, lead optimization, chemical biology, natural products chemistry and combinatorial and diversity oriented synthesis. This course is geared to upper level undergraduate students in chemistry or biochemistry, and first year chemistry graduate students. A strong understanding of organic chemistry is required.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development. Med Chem II builds on the material in Med Chem I and focuses on specific drug targets such as enzyme, G-protein coupled receptors, channels, nucleic acids and protein-protein interactions. Additionally, therapeutics area specific medicinal chemistry and drug discovery applications will be covered including anti-cancer agents, anti-infectives (antibiotics and anti-virals), and therapeutics to treat psychiatric and neurodegenerative disorders. This course is geared to upper level undergraduate students in chemistry or biochemistry and graduate students. Completion of Session I is a prerequisite. 0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Prerequisite

CHEM 7420

This course focuses on concepts and strategies in medicinal chemistry, and how it is applied to modern drug discovery and development. Topics include the drug discovery process, drug targets (GRCR?s, enzymes, channels etc.), physical chemistry of molecular interactions between drug and target, drug design, methods for hit and lead identification, lead optimization, chemical biology, natural products chemistry and combinatorial and diversity oriented synthesis. G-protein coupled receptors, channels, nucleic acids and protein-protein interactions. Additionally, therapeutics area specific medicinal chemistry and drug discovery applications will be covered including anti-cancer agents, anti-infectives (antibiotics and anti-virals), and therapeutics to treat psychiatric and neurodegenerative disorders.This course is geared to upper level undergraduate students in chemistry or biochemistry, and first year chemistry graduate students. A strong understanding of organic chemistry is required. 1 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The course deals with topics in Heterocyclic Chemistry. It covers nitrogen-containing monocyclic hetero rings, examining the most recent syntheses, the reactions and their mechanisms. The course will focus on recent variations and improvements of known heterocycles as well as their synthetic utility. Students will be expected to read critically a rece article on heterocyclic chemistry and do a presentation to the class.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This class will discuss selected topics related to Bioinspired synthesis, methods, tactics and strategies. Target molecules, methods and strategies are designed by using biological systems as models.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The focus of this course comprise the development of two synthetic strategies to access architecturally complex natural products of biological significance exploiting innovative chemistry. Lectures towards this end are given. As a project, each studnet is given a different complex natural product and expected at the end of the course to deveop two strategies, one based on asymmetric induction to provide the absolute stereochemical structure, the second where the absolute stereochemistry derives from commercially available starting materials.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Natural products such as tetrodotoxin, kainic acid ,and morphine have played a crucial role in the development of neuroscience. Using selected chemical syntheses as a framework, I will provide an introduction to neuroscience for chemists blended with a course in synthetic design. The structure function and synthesis of the following molecules will be analyzed: tetrodotoxin, saxitoxin, kainic acid, nicotine epibatidine, coniine, histrionicotoxin, strychnine, chrysanthemic acid, morphine, salvinorin A, THC, lysergic acid, huperzin A. galanthamine, cocaine, reserpine, capsaicin. resiniferatoxin, retinal, carotene menthol, camphor and the prostaglandins. The structure and function of important ion channels, GPCRs transporters, and enzymes and their ligands will be discussed using PyMol files. Goals: The goal of this course is to get as many synthetic chemists excited about neuroscience as possible (and a few neuroscientists stoked about synthesis). The importance of structural and pharmacological databases (PDB and IUPHAR, respectively)m and the usefulness of the Reaxys database (and SciFinder) for synthetic planning will be demonstrated. Requirements: A familiarity with synthetic organic chemistry and (named) chemical reactions a mastery of the Nernst equation and a willingness to learn more about one of the greatest if not the greatest scientific challenges of our times: to figure out how the human brain works. 0.5-1 Course Unit nt

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course will include a review of basic reaction mechanisms, stereoelectronic effects, functional groups and acid-base chemistry. The course will emphasize the writing of mechanisms using the curved-arrow notation and organic reactions. Bonding and electronic structure theories and more involved mechanisms will be discussed. Students are expected to have a good working knowledge of reactions, functional groups, stereochemistry and mechanisms from undergraduate organic chemistry. Students will be expected to review basic concepts in Organic Chemistry and spectroscopy. The course will include lectures and recitations, and students are expected to attend and participate.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course will provide an introduction to methods and applications of contemporary biochemical techniques and instrumentation used for analysis of biomolecules, including proteins, DNA/RNA and metabolites. Topics covered will include chromatographic and electrophoresis, mass spectrometry, fluorescence microscopy for the detection, characterization and structural analysis of proteins, antibodies and nucleic acids. The focus of the course will be applications in bioanalysis, biopharmaceuticals and biotechnology.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course will introduce topics in Chemical Biology and pharmacology and how they are applied for both basic and translational research. The course is focused on how basic science technology can be applied to discover a drug. The main components include: (1) selection of a disease with a focus on rare diseases (2) selection of a drug target, and (3) determining whether or not a small molecule interaction with that target can be expected to produce a therapeutic response. Key concepts of small molecule drug discovery are discussed throughout the course. Key technologies such as chemical proteomics and targeted degradation are covered. The advantages and disadvantages of therapeutic small molecules versus biologics will be discussed.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course introduces modern bioanalytical approaches used to measure and interpret metabolites and proteins in complex biological systems. Students will learn the principles and practical aspects of mass spectrometry, chromatography, and sample preparation as applied to metabolomics and proteomics. Emphasis will be placed on experimental design, quantitative analysis, and biological interpretation of data. The course bridges chemistry and biology, training students to apply analytical chemistry tools to real biological and biomedical questions. 1 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Ligands have a remarkable ability to alter the properties of metal ions, and the study of this coordination chemistry underlies many modern advances in science, including energy harvesting and storage, chemical catalysis, and sustainability. This course explores the relationships between the identities of ligands and the physical manifestations that result from their binding to metal centers. Topics to be covered include: symmetry and chirality in molecular complexes, variations in coordination number, ligand field effects, recent advanced in bonding theory, and inorganic reaction mechanisms.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

An introduction to the theory and practice of small molecule structure determination by X-ray crystallography. Topics discussed include point group and space group symmetry, structure factor theory, data collection methodology and a survey of solution methods. The course will include case studies of real-world structure determinations and interpreting X-ray structures.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

A continuation of X-ray I. This course will focus on the practical component of X-ray crystallography. Students will use crystallographic software (OLEX2, CrysAlisPRO, ShelX suite) to solve, refine, and finish small molecule crystal structures. These will include case studies and crystallographic problems such as the various types of disorder and twinning.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

or PHYS 5532Quantum Mechanics II

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The course encompasses the descriptive chemistry, and topics related to, the f-block including the rare earth metals and actinides. Coverage includes coordination chemistry and periodic trends, electronic structure and magnetism, and modern applications of f-block chemistry including lanthanide ions as spectroscopic probes, separations chemistry, materials chemistry and applications, organo-f-element chemistry, the chemistry of the actinides and transactinides, and reactivity/catalysis with f-block compounds.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

The goal of this course is for students to gain an understanding of the principles of electrochemistry along with some practical experience. Potentiometric methods will be discussed in the context of electrochemical equilibrium. Amperometric analytical methods -- chronoamperometry, chronocoulometry, stripping voltammetry, cyclic voltammetry, pulse polarography, AC impedance, and hydrodynamic methods -- will be described from the perspective of mathematical models of mass transport and electrode kinetics. As time permits, special topics and applications, such as electrochemical energy conversion, spectroelectrochemistry, photoelectrochemistry, ultramicroelectrodes, microfluidics, corrosion, electrochemical synthesis, and scanning electrochemical microscopy, will be covered. To complement and reinforce the material learned in class, students will fabricate electrodes, perform cyclic voltammetry and other experiments, and analyze electrochemical data. Equipment will be available in the instructor's research laboratory to do these experiments in small groups on students' own time outside of class. The instructor will provide out-of- class assistance to students who are not yet familiar with the use of electrochemical equipment. 1 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

This course will provide a fundamental understanding of symmetry, the character tables, how to derive these, and apply them in spectroscopy, and molecular orbital diagrams. The course will require some fundamental understanding of matrix algebra, and apply concepts of symmetry to derive character tables, predict spectroscopic properties of molecules, and derive molecular orbitals diagrams including hydridized orbitals. 0.5 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Chemistry Dissertation StatusTwo Term Class, Student may enter either term; credit given for either3 Course Units

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

Chemistry Master's Thesis Status

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

For students submatriculating in the Chemistry MS. Students carry out mentored research within the groups of individual faculty investigators on or near the Penn campus. Students commit a minimum of 15 hours/ week to original research in their host laboratories. In addition to research and assignments, students meet to present and discuss scientific research. Course activities and assignments complement the research effort. Developing effective scientific presentations is an emphasis. Each student must contact the course instructor with information regarding research group (faculty principal investigator) in the spring term prior the fall term of CHEM 9997. Two Term Class, Student may enter either term; credit given after both terms are complete 1 Course Unit

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu

(1) Advanced study and research in various branches of chemistry. (2) Seminar in current chemical research. (3) Individual tutorial in advanced selected topics.

Subject

CHEM

Type

course

Edition

2026-2027

Source

catalog.upenn.edu