22 courses with the subject PHRM, each shown exactly as we captured it from the college's catalog, with every element we hold. Where the wording looks broken, that is our reading of the catalog, not the college's text.
The goals of this course are three-fold: 1) Provide an overview of major psychiatric disorders. 2) Provide in-depth information on neurotransmitters, emphasizing the wealth of new molecular information on how neurons function and communicate, as well as the basis for psychotherapeutics (one class per week). 3) Develop skills to appreciate, present and critically evaluate the the current literature in neurotransmitter signaling and neuropsychopharmacology (one class per week). Prerequisite: Permission of course director Spring, even numbered years only Also Offered As: NGG 5100 1 Course Unit
This course will present a survey of the physiology of most of the major organ systems. It will integrate knowledge of cellular and molecular mechanisms into an understanding of function at the tissue, organ, and organism levels. It will begin with a brief review of membrane physiology, followed by electrophysiology and signaling in nerve. Then, after a brief outline of neural control systems and their role in homeostasis, it will present motility and muscle, the cardiovascular system, respiration, the renal and gastrointestinal systems, and selected topics from the endocrine system, the reproductive systems, environmental and exercise physiology. As well as providing a basis of integrative physiology for students in fields such as physiology, bioengineering and pharmacology, it should be of interest to students of cellular and molecular biology and genetic engineering who will need to appreciate the roles of specific systems and molecules at higher levels of organization. Prerequisite: Although not a formal prerequisite, a good foundation in cell bio level of BIOM/CAMB 6000 (or an equivalent upper level undergraduate strongly recommended. A general understanding of the chemistry a biochemistry of macromolecules, and of basic molecular biology is assumed. This course is primarily designed for 2nd year BGS students in BGS or other programs will require the permission instructor. This course is not open to undergraduates.
This course will survey methods and questions in experimental genomics, including next generation sequencing methods, genomic sequencing in humans and model organisms, functional genomics, proteomics, and applications of genomics methods. Students will be expected to review and discuss current literature and to propose new experiments based on material learned in the course. Prerequisite: Undergraduates and Masters students need BIOL 431. Also Offered As: GCB 5340 1 Course Unit
Second year students in GCB, CAMB (G&E), or IGG programs using genomics methods to measure transcriptomics and epigenomics changes in their experimental systems. The goal is to familiarize students with the latest cutting-edge genomics tools and cover solutions to major experimental and computational challenges in the investigation of genome-wide epigenetic data sets. Students will develop competence in (i) variations of experimental techniques improving resolution and throughout, (ii) issues related to the computational analyses closely related to the various genome-wide assays used to probe epigenetic processes and signals, (iii) computational approaches useful to overcome pitfalls associated to the analysis of a given epigenetic data modality, (iv) methods, techniques and studies on the integration of multi-layer epigenetic data sets.
TiMM is planned as a once-weekly seminar course whose goal is to introduce students to the ways in which biomedical research can provide new insights into clinical medicine and, conversely, how knowledge of clinical disease impacts scientific discovery. There are two sections for the course -- 401 and 402. Section 401 is for first year MD/PhD students only and section 402 is for VMD/PhD and PhD students.
PHRM 5700Principles of Cardiovascular Biology: Vascular biology
medicine and engineering Lectures to be presented by various Medical School faculty members. Topics covered include: general principles of vascular biology and hemodynamics, endothelial cells and integral vascular functions, signaling in the cardiovascular system, angiogenesis, hemostasis and thrombosis, platelets, platelet/vascular interactions, vascular integrins and adhesion molecules, vascular inflammation and oxidative stress, white blood cells, vasoactive compounds and drugs, mechanisms of atherosclerosis, cholesterol and lipid metabolism, hypertension, novel vascular directed gene and enzyme therapies. Permission of course director required to enroll.
This is a "literature-based" course (i.e. a seminar course/literature survey). It will survey the emerging technologies and computational advances that have permitted the field of Pharmacogenomics to mature into a major biomedical discipline over the past few years. It will consider the likely impact on disease target identification; the development of new drugs for established and "niche" markets; the advent of "personalized medicine" including the selection of therapies that have maximum efficacy and minimum side-effect profiles. This course will also touch on some of the ethical issues associated with the routine genetic testing of patients to facilitate treatment choices and clinical monitoring.
PHRM 5900Molecular Toxicology: Chemical and Biological Mechanisms
Course Goals: Exposures to foreign compounds (drugs, carcinogens, and pollutants) can disrupt normal cellular processes leading to toxicity. This course will focus on the molecular mechanisms by which environmental exposures lead to end-organ injury and to diseases of environmental etiology (neurodegenerative and lung diseases, reproduction disruption and cardiovascular injury). Students will learn the difficulties in modeling response to low-dose chronic exposures, how these exposures are influenced by metabolism and disposition, and how reactive intermediates alter the function of biomolecules. Mechanisms responsible for cellular damage, aberrant repair, and end-organ injury will be discussed. Students will learn about modern predictive molecular toxicology to classify toxicants, predict individual susceptibility and response to environmental triggers, and how to develop and validate biomarkers for diseases of environmental etiology. Students are expected to write a term paper on risk assessment on an environmental exposure using available TOXNET information. Pre-requisites: Must have taken or will take Fundamentals of Pharmacology concurrently. Undergraduate course work in biochemistry and chemistry essential. Exceptions allowed based on past course work. Please consult with students with required prerequisites; residents in in Environmental and Occupational Health, and professional masters students (MPH and MTR).
This course is designed to introduce students to basic pharmacological concepts with special emphasis on the molecular actions of drugs. Subject matter includes use of microcomputers to analyze pharmacological data. Only open to students in the Pharmacology Graduate Group.
This course surveys the major classes of drugs used to treat human conditions, and focuses in the detail on their molecular mechanisms of action. It consistsof two 2-hour lectures per week and problem sets. Student evaluation is based 50% on exams and 50% on problem sets. PHRM 624 is required of all 2nd year PGG students. PGG students must co-enroll in PHRM 532/CAMB 532 (Human Physiology). Prerequisite: Non- PGG students must have permission from course director to enroll. 2 Course Units
PHRM 6320Cell Control by Signal Transduction Pathways
This course, "Targeting the cancer cell: from mechanism to precision medicine", will examine how various signal transduction mechanisms influence cell functions including replication, growth, transcription, translation and intracellular trafficking. We will also consider how non- cell autonomous mechanisms, such as the tumor microenvironment and the immune system influence cancer cell signaling. We will consider how important signaling pathways, such as Ras, Raf, Notch, Wnt, TGF beta, and various kinases/phosphatases become dysregulated in cancer, as well as delve into how the DNA damage response, immune system, and tumor microenvironment exert important influences on oncogenic signaling. In the first half of the course, invited faculty members will pick 2 relatively recent papers from their field that highlight important areas. Each paper will be assigned to a student, who will meet with the faculty mentor prior to the class to discuss the paper and their presentation. During the class, students will present each paper for approximately 45 minutes with time for discussion. Students will present the important background, break down the paper, look for strengths and weakness and come up with a plan of what the next set of experiments could or should be. In the second half of the course, students will independently pick a relevant paper for in class presentation and will also write a short "News and Views" style article based on the paper they have chosen. The goal of the course is to provide students with a view of the cancer cell that integrates both cell autonomous and non-cell autonomous signals and to use this information to consider how to successfully treat cancer.
