North Carolina State University at Raleigh · Courses
BME
80 courses with the subject BME, each shown exactly as we captured it from the college's catalog, with every element we hold. Where the wording looks broken, that is our reading of the catalog, not the college's text.
BME 201Computer Methods in Biomedical Engineering (3
hours) Students develop computer-based problem solving techniques using Excel and MATLAB to solve introductory problems in Biomedical Engineering. Emphasis is on developing solution algorithms, implementing these with spreadsheets and computer programming, and presenting results in a clear and concise manner. Students registered for BME 201 who fail to matriculate into BME will be dropped from the course. Typically offered in Fall only
Study of the state of rest or motion of bodies subjected to the action of forces. Properties of force systems, free body diagrams, concepts of equilibrium, kinematics and kinetics of particles, Newton's laws, kinematics of rigid bodies and their applications in biomedical systems. BME 205 and (CE 214 or MAE 206). Typically offered in Fall and Spring
BME Majors Only. Credit cannot be received for both
BME 207Biomedical Electronics ()4
Fundamentals of analog and digital circuit analysis and design as applied to biomedical instrumentation and measurement of biological potentials. Passive circuit components, node and mesh analysis, transient behavior, operational amplifiers, frequency response, analog filter design, diode, transistors, biological signal acquisition, binary math and logical operators, digital circuit design, circuit simulation tools and techniques. Laboratory exercises supplement the topics presented in class lectures. Typically offered in Spring only
This laboratory is part of BME 205 - Biomedical Mechanics and complements it with relevant labs and examples. Statics and dynamics subjects will be studied with experimental techniques and computational methods. Forces, moments, kinetic, and kinematic properties will be measured in the human system and medical devices. Typically offered in Fall and Spring Biomedical Engineering (BME) 1
Laboratory in analog and digital circuit analysis. Electrical safety; Exercises in resistor networks, capacitors and inductors, steady-state and dynamic circuit behavior, active circuits, amplifiers, logic gates, combinatorial and sequential circuits, elementary digital system design, A/D conversion, biomedical applications. Typically offered in Spring only
Introductory laboratory experience focused on integrating biological engineering and materials engineering principles by exploring key topics in materials science. Topics include biomaterial fabrication, evaluation of their physical properties and interpretation of results. received for both BME 219 and BME 209 Typically offered in Fall and Spring
MSE 200 or MSE 201 or MSE/BME 203. Credit cannot be
BME 290Special Topics in Biomedical Engineering (1-4
hours) A study in the special fields under the direction of the faculty. Offered as needed for presenting material not normally available in regular BME courses. Typically offered in Fall, Spring, and Summer
Undergraduates (1-3 credit hours) Opportunity for faculty mentored research in biomedical engineering. Approved plan of work required with significant independent research culminating in a final paper. Students must identify an advisor or co- advisor from within the BME faculty with whom to work on a regular basis. The advisor and BME Undergraduate Affairs Committee must approve th the student project prior to the student registering for the course. R: BME Majors, Departmental Approval Required Typically offered in Fall and Spring
This course includes a quantitative approach to human physiology from the biomedical engineering perspective with an emphasis on neural, sensory, muscle, and cardiac physiology. Autonomic and somatic motor control will be discussed. Engineering applications, including neural stimulators, functional imaging, cochlear implants, artificial noses, vestibular implants, visual implants, artificial larynges, pacemakers and defibrillators will be discussed. Assignments include computer-based exercises using MATLAB. Typically offered in Fall only
This course explores a quantitative approach to human physiology from the biomedical engineering perspective with an emphasis on systems physiology described using mechanical properties. Topics include the physiological and mechanical behavior of the blood vessels, lungs, kidney muscles and larynx. In the course lab exercises, students investigate mechanical properties of fluids, electrolyte exchange in dialysis, spirometry and blood pressure measurement among other topics. The course culminates with the design of a novel laboratory experiment. BMME 150] Typically offered in Spring only
Quantification and modeling of heat and mass transfer in biomedical systems. Topics include heat transfer rate equations, conservation of energy, steady-state and transient heat transfer, Brownian motion, Fick's laws, conservation of mass equations, molecular transport through membranes, porous media, Stoke-Einstein relations, boundary layer theory, mass transfer coefficients and hemodialysis. Typically offered in Fall only
An overview of how alterations in bioenergetics, enzyme catalysis, protein and membrane structure, carbohydrate, lipid and nucleic acid metabolism affect human health and how biomedical engineering tools are used to detect and monitor the problems by understanding these biochemical processes. Topics include: Biological Thermodynamics, Energy of macromolecular structure and binding, Structure/function of proteins, enzymes and nucleic acids, Kinetics, enzyme catalysis and biochemical network analysis, Generation of chemical and electrical potential in membranes, Carbohydrate/lipid/protein metabolism and energy production, DNA synthesis, transcription, Technologies used to monitor/detect biochemical processes including clinical imaging modalities. or BM[M]E 219); Restriction: No credit allowed for BM[M]E 325 AND [BCH 351 or BCH 451] Typically offered in Fall only
Fundamental sciences behind the design and selection of biomaterials, including crystallography, polymer science, characterization, mechanical testing, and surface preparation. Integration of biomaterials into the body and its response, including inflammation and rejection. Semester-long research project. Pre-req: BIO 183, (BM[M]E 209 or MSE 201) Typically offered in Spring only
This course covers topics ranging from multi-body systems to stress superposition to failure criteria to prepare students for the more advanced subjects of biomechanics and rehabilitation engineering. Topics include the following: Free-body diagrams, Multibody statics and dynamics, Linkage kinematics and kinetics, Anthropometric kinematics, Stress/ strain/torsion, Beam bending, Stress superposition, Constitutive relationship, Strain gauges, Finite-element analysis, Failure analysis, Failure mechanisms. Typically offered in Spring only
Quantitative analysis of dynamic and feedback control systems, including modeling of physiological systems and physiological control systems, system time and frequency responses, control characteristics, and stability analysis. Design techniques for feedback systems in biomedical applications. MA 331 or MA 341 Typically offered in Spring only Graduate Catalog 979
BME 365Linear Systems in Biomedical Engineering (3
hours) Fundamentals of linear systems analysis as applied to problems in biomedical modeling and instrumentation. Properties of biomedical systems and signals. Representation of continuous- and discrete-time signals and system response. Convolution. Fourier analysis in continuous and discrete domains. Laplace transform. Frequency response and its application in biomedical systems. Filter design. Circuit analogs to mechanical and thermodynamics systems and their applications in modeling biomedical systems. Applications in biomedical instrumentation. Students use MATLAB to simulate and analyze biomedical linear systems. BME majors only. 217); Corequisites: MA 341 or MA 331 Typically offered in Fall only
Overview of microcontroller-based systems, including applications, architecture, number systems, and languages. Students gain experience using a PIC-based microcontroller to input information from a user and output information using LEDs and LCD displays. Student will learn capabilities of the PIC through in class exercises and weekly programming assignments. Both assembly language and PIC-based C are used. Students develop a PIC-based heart rate monitor and work in pairs on a BME-related project of their choice. MA 341 Typically offered in Spring only
Fundamentals of biomedical instrument design and implementation. Sensing mechanisms, sensor interfacing circuits, analog-to-digital conversion, biosignal capture and storage, embedded microprocessors, system integration and prototyping. Typically offered in Fall only
Fundamentals of continuous- and discrete-time signal processing as applied to problems in biomedical instrumentation. Properties of biomedical signals and instruments. Descriptions of random noise and signal processes. Interactions between randombiomedical signals and systems. Wiener filtering. Sampling theory. Discrete-time signal analysis. Applications of Z-transform and discrete Fourier transform. Digital filter design methods for biomedical instruments. BME or MS or PHD; credit not allowed for both BME 412 and BME 512. Pre-reqs: BM(M)E 365 or BME 311 Typically offered in Fall only
hours) This course is part of a three year sequence and it expands on the skills and knowledge gained in BM(M)E 398. Students continue to learn the process of engineering design and learn new skills to produce solutions for unmet medical needs. Pre-reqs: BME 398, BME 301 or 302, 2 gateway or specialty electives completed Typically offered in Fall only
Strategy (3 credit hours) This course is part of a three-year sequence and it expands on the skills and knowledge gained in prior design courses. Students continue to learn the process of engineering design and learn new skills to produce solutions for unmet medical needs. Implementation phase of the senior design experience. l gateway or specialty electives completed Typically offered in Spring only BME 456/BME 556 Rehabilitation Robotics (3 credit hours) This course explores the use of robotic and mechatronic technology to restore function in individuals with sensorimotor impairment. The theoretical framework will be introduced for assessment and design of both assistive and therapeutic applications. Students will create a computer model of movement of limb in conjunction with a mechatronic device. P: [BM[M]E 205 or BM[M]E 215] and BM[M]E 302 and [BM[M]E 355 or BM[M]E 365 or BM[M]E 375] Typically offered in Fall only BME 457/BME 557 Neural Engineering (3 credit hours) Principles and technologies of neuroengineering and clinical applications in neuromotor rehabilitation; basic human neurophysiology; bi-directional neural-machine interfaces; neuromodulation for motor function improvement; artificial visual/auditory devices for augmented sensory perception. Typically offered in Spring only
BME 490Special Topics in Biomedical Engineering (1-4
hours) Offered as needed for presenting material not normally available in regular BME Department courses or for new BME courses on a trial basis. Typically offered in Fall, Spring, and Summer
First in a two-semester sequence of research courses that partially fulfills the requirements for graduation with departmental honors. Prior approval needed for enrollment. Students should identify a research mentor and research topic before applying. Minimum GPA requirement and written report are required. The course does not meet a graduation requirement, and can only be used to meet the requirements of graduation with departmental honors.
Project approval by the BME Undergraduate Research
BME 492Biomedical Engineering Honors Thesis II ()3
Second in a two-semester sequence of research courses that partially fulfills the requirements for graduation with departmental honors. Students work with a mentor on an independent research project. Minimum GPA requirement and written report are required. The course does not meet a graduation requirement if used to meet the requirements of graduation with departmental honors. Undergraduate Research Committee Typically offered in Spring only Biomedical Engineering (BME) 5
BME 491 and project continuation approval by the BME
BME 495Undergraduate Research in Biomedical Engineering (3
credit hours) Opportunity for hands-on faculty mentored research project in biomedical engineering. Course may be a stand-alone project completed in one semester/summer or serve as part of a two-semester project. Approved plan of work required with significant independent research culminating in r a final paper and presentation at the NC State Undergraduate Research Symposium or other appropriate venue. Students must identify an advisor from within the BME faculty with whom to work on a regular basis. The advisor must approve the student prior to the student registering for the course. The BME Undergraduate Coordinator must approve the use of the course as a restricted elective for the BME degree. Departmental Approval Required. Individualized/Independent Study and Research courses require a Course Agreement for Students Enrolled in Non- Standard Courses be completed by the student and faculty member prior to registration by the department.
BME 501MedTech Innovation and Entrepreneurship I - Needs
Discovery (4 credit hours) This course utilizes clinical immersion to identify medical device and other healthcare opportunities. Students will be exposed to diverse healthcare environments and learn to triage opportunities based on financial, regulatory and intellectual property landscapes. Guest lectures will feature experts in the medical device, pharmaceutical and healthcare industries as well as local entrepreneurs. in the M.S. Biomedical Engineering - MedTech Innovation and
Graduate Standing; R: Restricted to students enrolled
BME 502MedTech Innovation and Entrepreneurship II - Design and
Regulation (4 credit hours) This course teaches path-to-market concepts including regulatory aspects unique to medical devices and pharmaceuticals. Topics include detailed analyses of Phase I-IV clinical trials, 510(k) and PMA approvals, Investigational Device Exemption (IDE) Investigational New Drug (IND) application, Good Laboratory Practices (GLP) and clinical research organizations (CROs). Students will participate in frequent visits to local biotech companies. Guest lectures will feature experts in FDA processes, clinical research and early stage biotech ventures. in the M.S. Biomedical Engineering - MedTech Innovation and
Graduate Standing; R: Restricted to students enrolled
BME 503MedTech Innovation and Entrepreneurship III - Product
Development (4 credit hours) This course covers product development and project management for new biomedical-related products from accessing various streams of funding to allocation of resources for rapid prototyping and scale- up manufacturing. Students will visit local biotech companies and prototyping facilities. A guest lecture series will feature best practices from entrepreneurs and industry practitioners. in the M.S. Biomedical Engineering - MedTech Innovation and
Graduate Standing; R: Restricted to students enrolled
BME 504Medical Device Materials and Manufacturing (3
hours) This course will immerse students in state-of-the-art medical device materials and manufacturing methods. Students will explore materials that are commonly used in medical devices, including metals such as nitinol and various grades of stainless steels, as well as engineering plastics such as PEEK and sustainable materials such as renewable polyethylene (PR) and polyethylene terephthalate (PET). The course will also introduce common manufacturing methods and design guides for each of the materials covered with the students responsible for the design and manufacture of components and subassemblies to demonstrate an understanding of the techniques. Finally, the students will be required to leverage some of these materials and manufacturing techniques to develop components and assemblies for use in their solutions for the needs identified in BME 501 and further developed in BME 502 and 503. Restriction: Graduate Standing in M.S. Biomedical Engineering Program Typically offered in Fall only
Fundamentals of continuous- and discrete-time signal processing as applied to problems in biomedical instrumentation. Properties of biomedical signals and instruments. Descriptions of random noise and signal processes. Interactions between random biomedical signals and systems. Wiener filtering. Sampling theory. Discrete-time signal analysis. Applications of Z-transform and discrete Fourier transform. Digital filter design methods for biomedical instruments. Biomedical applications of filter design, signal restoration, and signal detection. Typically offered in Fall only BME 518/ECE 518/ECE 418/BME 418 Wearable Biosensors and Microsystems (3 credit hours) This course surveys the methods and application of wearable electronics and microsystems to monitor human biometrics, physiology, and environmental conditions. Topics covered include wearable electrocardiograms, blood-glucose monitors, electronic tattoos, wearable energy harvesting, "smart" clothing, body area networks, and distributed population networks. Critical comparison of different sensor modalities, quantitative metrics, and how their limitations in realistic applications define the selection, design, and operation criteria of one type of sensor over another will be considered. Typically offered in Fall only BME 522/ECE 522 Medical Instrumentation (3 credit hours) Fundamentals of medical instrumentation systems, sensors, and biomedical signal processing. Example instruments for cardiovascular and respiratory assessment. Clinical laboratory measurements, theraputic and prosthetic devices, and electrical safetyrequirements. Students should have background in electronics design using operational amplifiers. Typically offered in Fall only BME 525/BME 425 Bioelectricity (3 credit hours) Quantitative analysis of excitable membranes and their signals, including plasma membrane characteristics, origin of electrical membrane potentials, action potentials, voltage clamp experiments, the Hodgkin- Huxley equations, propagation, subthreshold stimuli, extracellular fields, membrane biophysics, and electrophysiology of the heart. Design and development of an electrocardiogram analysis system. Typically offered in Spring only BME 529/BME 429 Cellular Engineering (3 credit hours) Cellular Engineering utilizes engineering principles to solve problems in cellular and molecular biology, particularly in the context of regenerative medicine and cell therapies. This course will cover a broad range of topics that allow for quantitative analysis and manipulation of cellular and subcellular processes. Topics covered in this course include: cell growth kinetics; enzyme kinetics; signal transduction networks; genetic engineering; receptor-ligand interactions; quantitative analysis of cell-cell and cell-material adhesion; mechanisms of mechanotrandsuction; and commercialization and scale-up. P: BME 325 or BMME 325 or BCH351 Typically offered in Fall only BME 538/BME 438 Bone Mechanobiology (3 credit hours) This course focuses on understanding the biology and mechanics of bone tissue, in healthy and altered states such as in injury, aging, and disease. Topics include: skeletal anatomy and physiology; bone tissue composition, structure, and function; mechanical behavior of bone at cell, tissue, and organ levels; skeletal functional adaptation to its mechanical environment; and experimental and analytical methods in bone mechanics and mechanobiology. Fundamental research in the field and clinical applications are discussed. P: BME/BMME 335 or BME/BMME 345 or MAE 214 or CE 225 Typically offered in Spring only
Student multidisciplinary teams work with local medical professionals to define specific medical device concepts for implementation. Medical specialty immersion with clinical departments at local medical centers; design input based on stakeholder-needs assessment' market analysis and intellectual property review; new medical devices with broad markets; design output and device specification; product feasibility and risk assessment; design for medical device manufacturing. Typically offered in Fall only BME 556/BME 456 Rehabilitation Robotics (3 credit hours) This course explores the use of robotic and mechatronic technology to restore function in individuals with sensorimotor impairment. The theoretical framework will be introduced for assessment and design of both assistive and therapeutic applications. Students will create a computer model of movement of limb in conjunction with a mechatronic device. P: [BM[M]E 205 or BM[M]E 215] and BM[M]E 302 and [BM[M]E 355 or BM[M]E 365 or BM[M]E 375] Typically offered in Fall only BME 557/BME 457 Neural Engineering (3 credit hours) Principles and technologies of neuroengineering and clinical applications in neuromotor rehabilitation; basic human neurophysiology; bi-directional neural-machine interfaces; neuromodulation for motor function improvement; artificial visual/auditory devices for augmented sensory perception. Typically offered in Spring only
BME 560Medical Imaging: X-ray, CT, and Nuclear Medicine
Systems (3 credit hours) Overview of medical imaging systems using ionizing radiation. Interaction of radiation with matter. Radiation production and detection. Radiography systems and applications. Tomography. PET and SPECT systems and applications. Biomedical Engineering (BME) 7 BME 563/BME 463 Biomedical Optics and Lasers (3 credit hours) This course will focus on non-invasive methods/techniques that use visible light/NIR/UV to monitor biological processes in humans, animal models and cells. The first part of the course will focus on the basic principles of light (e.g. radiation transport equation) and light-tissue interactions. The second part will focus on a variety of spectroscopic and imaging methods, flow cytometry and more. Applications include: The pulse oximeter, monitoring metabolic activity and non-invasive diagnosis of diseases. The course is designed for biomedical engineering students who plan to work in the medical device industry. Typically offered in Spring only BME 564/BME 464 Microscopy (3 credit hours) The course is an introductory class to microscopy. This course aims to build the intuition that engineers use to understand optical systems and will cover the basic principles of light, such as reflection and refraction, light-wave characteristics, polarization, interference, coherence and more, with an emphasis on optical components that utilize these concepts. A particular focus will be on microscopy and geometrical optics and multiple topics in this area such as: the Abbe theory of image formation, darkfield imaging and fluorescence microscopy. Recent literature in the field will be reviewed and complex imaging systems simplified in order to understand their design principles. The course is designed for biomedical engineering students who plan to work in the medical device industry. Typically offered in Spring only BME 566/TE 466/BME 466/TE 566 Polymeric Biomaterials Engineering (3 credit hours) In-depth study of the engineering design of biomedical polymers and implants. Polymeric biomaterials, including polymer synthesis and structure, polymer properties as related to designing orthopedic and vascular grafts. Designing textile products as biomaterials including surface modification and characterization techniques. Bioresorbable polymers. (MAE 206 or CE 214) Typically offered in Fall only
BME 311, ST 370 or ST 371, and PY 208 (MA 331 or MA 341) and [BM[M]E 301 or BMME 302] (MA 331 or MA 341) and [BM[M]E 301 or BM[M]E 302] PY 208 and (TE 200 or CH 220 or CH 221 or CH 225) and
The immune system influences nearly all aspects of human health and therefore deserves consideration by investigators developing devices, drugs and strategies to improve human health. The course begins with a brief review of the immune system, fundamental immunological assays and the role of the immune system in disease. The second part of the course focuses on immune responses to a range of biomaterials. The third part will explore immune responses in the context of vaccines, immunotherapies and regenerative medicine. P: Graduate Standing Typically offered in Spring only
Chemical, physical, biological, and engineering aspects of nanostructured materials used in medical implants. (MSE) 203), Human Physiology for Engineers I (BME 301) and Human Physiology for Engineers II (BME 302). Equivalent courses accepted at discretion of instructor. Typically offered in Spring and Summer BME 577/BME 477 Data Science and Machine Learning in Medicine (3 credit hours) Methods of data science and machine learning in the context of medical decision support. Types of data and models. Data visualization. Descriptive statistics. Analysis of variance. Dimensionality reduction. Clustering. Models and evaluation methods for classification problems and estimation problems. Deep learning. Extensive use of MATLAB. Typically offered in Spring only BME 581/BME 481 Quality Management Systems for Engineers (3 credit hours) This course is designed for biomedical engineering students who plan to work in industry. The course covers industry related topics including team work, conflict resolution, manufacturing and specifications, gap analysis, and root cause of analysis. Design topics including design of experiments, and standards and regulations relevant to the biomedical engineering profession are also covered. Lean and six sigma are taught with an option to test for a six sigma green belt if a six sigma project is completed in the following semester. Co-reqs: BMME 697 or BME 451 Typically offered in Fall only
BME 582Quality Management Standards for Biomedical
Engineers (3 credit hours) This course is designed for biomedical engineering students who plan to work in industry with a focus on manufacturing quality systems The course covers industry related to Quality System Management with an emphasis on using an ISO 13485 based QMS. Topics will include: ISO 13485 requirements, including requirements for ISO 13485 documentation (i.e. quality objectives, quality manual, procedures, work instructions, quality system records, etc). Other topics will include planning, conducting, and documenting an internal audit. At the end of the course the students may earn a NCSU-IES certification as an ISO 13485 internal auditor. R: Graduate Standing Typically offered in Spring only BME 583/BEC 583/BME 483/BEC 483 Tissue Engineering Technologies (2 credit hours) In this eight week laboratory course, students will gain practical experience with two key elements of tissue engineering: constructing a complex living tissue that closely resembles its natural counterpart, and assessing angiogenic potential for tissue engineering applications. Students will construct and induce maturation of multi-layered skin equivalents using dermal fibroblasts, keratinocytes, and various biomaterials, and employ paraffin embedding, sectioning, and staining techniques to examine the tissues. Students will investigate the capacity of compounds to induce angiogenesis in human cells using the Matrigel assay. Various biomaterials and angiogenic factors will be evaluated. permission of instructor. Typically offered in Fall only BME 584/BME 484 Fundamentals of Tissue Engineering (3 credit hours) This course covers essential concepts of organ and tissue design and engineering using living components, including cell-based systems and cells/tissues in combination with biomaterials, synthetic materials and/or devices. Topics include: In vivo tissue structure and function; Isolation and culture of primary cells and stem cells; Principles of cellular differentiation; Mass transport processes in cell culture systems; Design, production and seeding of scaffolds for 3D culture; Design of bioreactors to support high-density cell growth; State-of-the-art engineered tissue systems; Clinical translation; and Ethics. or TE 303 or BME 315 or BME 325) Typically offered in Spring only
Students obtain professional experience through advanced engineering work in industrial and commercial settings under joint supervision of a member of the graduate faculty and an outside professional. Typically offered in Fall and Spring
The Non-thesis MS in BME requires students to complete a Master's Project and defend the project orally. This independent study project may be used as a substitute for the regularly offered MS projects if approved by the BME Graduate Curriculum Committee. Typically offered in Fall, Spring, and Summer
Instruction in research and research under the mentorship of a member of the Graduate Faculty. Typically offered in Spring and Summer Graduate Catalog 985
For students who have completed all credit hour requirements and full- time enrollment for the master's degree and are writing and defending their thesis. Typically offered in Fall, Spring, and Summer
BME 702Biochemical Foundations of Biomedical Engineering (3
credit hours) An overview of how tools in rehab engineering, microdevices, pharmacoengineering and biomedical imaging are developed to detect and treat alterations in biochemistry that affect human health. Typically offered in Fall only
BME 802Advanced Seminar in Biomedical Engineering (1
hours) Elaboration of advanced subject areas, techniques and methods related to professional interest through presentations of personal and published works; opportunity for students to present and critically defend ideas, concepts, and inferences; opportunity for distinguished scholars to present results of their work. Discussions to uncover analytical solutions and analogies between problems in biomedical engineering and other technologies, and to present relationship of biomedical engineering to society. science, or biological science majors, or textiles Typically offered in Fall and Spring
Doctoral student in BME or other engineering, physical
BME 885Doctoral Supervised Teaching ()1-3
Teaching experience under the mentorship of faculty who assist the student in planning but the teaching assignment, observe and provide feedback to the student during the teaching assignment, and evaluate the student upon completion of the assignment. Typically offered in Fall, Spring, and Summer
